Team
Translational Epigenetics

Dpt: Signaling through Chromatin

Our research activities

We aim to explore chromatin signaling pathways, how their deregulation can lead to pathological states, which could be targeted to treat human diseases. Jérôme Govin launched his team in 2012 at the Bioscience and Biotechnology Institute of Grenoble (BIG). We have since been studying chromatin signaling pathways, histone acetylation and extensively characterizing the biology of acetyl-reader modules, bromodomains (BDs). In 2018, our team moved to the Department “Signaling Through Chromatin” of the Institute of Advanced Biosciences. It now includes a new research program lead by the senior scientist Anouk Emadali with several clinicians of the Hospital of Grenoble. This broadens the research field to the chromatin biology in onco-hematology, with a proficient expertise to address translational questions in epigenetics. Our team is driven by this central question: understanding cellular fate. Indeed, cell fate is conditioned by the regulation of gene expression. The genome is organized in the form of chromatin, in particular by histones. These mechanisms have been very well conserved during evolution, from yeast to man, and we are studying them in a physiological context, mainly gamete differentiation in mammals and in yeast, and in a pathological context, infectious diseases and cancer. Our projects combine cell biology, biochemistry, proteomics, structural biology and bioinformatics.
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Jérôme GOVIN

Team leader

04 76 54 95 84

Our research axes

This axis aims to study histone variants, chromatin in yeast spores and chromatin signaling in aggressive B lymphomas.

This axis studies BET proteins and their bromodomains in pathogenic fungi, in high-risk B Cell Lymphoma and inflammation

Our major publications

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Adverse outcome in follicular lymphoma is associated with MYC rearrangements but not MYC extra copies

Bussot L et al.

Br J Haematol 2021

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Extranucleolar CYCLON Staining Pattern Is Strongly Associated to Relapse/Refractory Disease in R-CHOP–treated DLBCL

Bouroumeau A, et al

HemaSphere 2021 Jun 12;5(7):e598

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De novo SMARCA2 variants clustered outside the helicase domain cause a new recognizable syndrome with intellectual disability and blepharophimosis distinct from Nicolaides-Baraitser syndrome

Cappuccio G, et al.

Genet Med . 2020 Nov;22(11):1838-1850. doi: 10.1038/s41436-020-0898-y. Epub 2020 Jul 22.

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Systematic genetic and proteomic screens during gametogenesis identify H2BK34 methylation as an evolutionary conserved meiotic mark

Crespo M, et al.

Epigenetics Chromatin 2020 13(1):35

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A phase 2 study of rituximab, bendamustine, bortezomib and dexamethasone for first-line treatment of older patients with mantle cell lymphoma

Gressin R, et al.

Haematologica 2019 104(1):138-146.

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BET Family Protein BRD4: An Emerging Actor in NFκB Signaling in Inflammation and Cancer

Hajmirza A, et al. 

Biomedicines 2018 6(1)

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Systematic quantitative analysis of H2A and H2B variants by targeted proteomics

El Kennani S, et al. 

Epigenetics Chromatin 2018 11(1):2

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Bdf1 Bromodomains are Essential for Meiosis and the Expression of Meiotic-Specific Genes

García-Oliver E, et al. 

PLoS Genet 2017 13(1):e1006541

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MS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones 

El Kennani S, et al.

Epigenetics & Chromatin 2017 10:2

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Selective BET inhibition as an antifungal therapeutic strategy

Mietton F, et al.

Nat Commun 2017 18;8:15482

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Our activities in pictures

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Our collaborations

  • Carlo Petosa, Institute of Structural Biology (IBS)
  • Charles McKenna, USC Los Angeles, USA
  • Guillermo Orsi, IAB
  • Julien Thévenon, IAB
  • Genaël Rabut, IGDR, Rennes
  • Dominique Helmlinger, CRBM, Montpellier

Our technologies

  • Molecular and cellular biology
  • Cell culture
  • Yeast genetics and biochemistry
  • B cell lymphomas
  • Advances epigenomics (RNA-seq, ChIP-seq, ATAC-seq, Cut&Run-seq, etc)
  • Bioinformatic analysis