Team
Translational Epigenetics
Dpt: Signaling through Chromatin
Our research activities
We aim to explore chromatin signaling pathways, how their deregulation can lead to pathological states, which could be targeted to treat human diseases.
Jérôme Govin launched his team in 2012 at the Bioscience and Biotechnology Institute of Grenoble (BIG). We have since been studying chromatin signaling pathways, histone acetylation and extensively characterizing the biology of acetyl-reader modules, bromodomains (BDs).
In 2018, our team moved to the Department “Signaling Through Chromatin” of the Institute of Advanced Biosciences. It now includes a new research program lead by the senior scientist Anouk Emadali with several clinicians of the Hospital of Grenoble. This broadens the research field to the chromatin biology in onco-hematology, with a proficient expertise to address translational questions in epigenetics.
Our team is driven by this central question: understanding cellular fate.
Indeed, cell fate is conditioned by the regulation of gene expression. The genome is organized in the form of chromatin, in particular by histones. These mechanisms have been very well conserved during evolution, from yeast to man, and we are studying them in a physiological context, mainly gamete differentiation in mammals and in yeast, and in a pathological context, infectious diseases and cancer.
Our projects combine cell biology, biochemistry, proteomics, structural biology and bioinformatics.
View the team website
Our research axes
This axis aims to study histone variants, chromatin in yeast spores and chromatin signaling in aggressive B lymphomas.
This axis studies BET proteins and their bromodomains in pathogenic fungi, in high-risk B Cell Lymphoma and inflammation
Our major publications
See all publicationsOur activities in pictures
Our collaborations
- Carlo Petosa, Institute of Structural Biology (IBS)
- Charles McKenna, USC Los Angeles, USA
- Guillermo Orsi, IAB
- Julien Thévenon, IAB
- Genaël Rabut, IGDR, Rennes
- Dominique Helmlinger, CRBM, Montpellier
Our technologies
- Molecular and cellular biology
- Cell culture
- Yeast genetics and biochemistry
- B cell lymphomas
- Advances epigenomics (RNA-seq, ChIP-seq, ATAC-seq, Cut&Run-seq, etc)
- Bioinformatic analysis