Team
INVADE: Physio-pathological invasion in tissue development and homeostasis

Dpt: Environnement, Reproduction, Infections, Cancer

Our research activities

The INVADE team aims to study the physiological and pathological processes of invasion. Our work focuses on gaining a comprehensive understanding of the physical principles and molecular mechanisms that enable cells to invade tissue. We work on a variety of cellular models (macrophages, endothelial cells, megakaryocytes, metastatic cancer cells, etc.), which allows us to propose targeted strategies aimed at limiting unwanted invasion by diseased cells while preserving physiological invasion such as during the immune response or platelet production.

Our studies integrate cell biology, synthetic biology, biophysics, bioinformatics, and advanced microscopy techniques through partnerships with national and international collaborators. Our project is structured around three key objectives, reflecting the common interests and synergy between the team's researchers.

Eva FAUROBERT

Team leader, DR2 CNRS

Olivier DESTAING

Team leader / Scientific coordinator - DR2 CNRS

130732-22102025-Image1.png See the whole team

Our research axes

Our major publications

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Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth

Shapeti A, Barrasa-Fano J, Abdel Fattah AR, de Jong J, Sanz-Herrera JA, Pezet M, Assou…

Nat Commun. 2024 Oct 6;15(1):8660. doi: 10.1038/s41467-024-52866-6. PMID: 39370485; PMCID: PMC11456588.

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Optogenetically controlled inflammasome activation demonstrates two phases of cell swelling during pyroptosis

Nadjar J, Monnier S, Bastien E, Huber AL, Oddou C, Bardoulet L, Leloup HB, Ichim…

Sci Signal. 2024 Apr 23;17(833):eabn8003. doi: 10.1126/scisignal.abn8003. Epub 2024 Apr 23. PMID: 38652763.

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Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch

Miroshnikova YA, Manet S, Li X, Wickström SA, Faurobert E*, Albiges-Rizo C*.

Mol Biol Cell 2021 Aug 19;32(18):1724-1736. doi: 10.1091/mbc.E21-03-0106. Epub 2021 Jun 3. PMID: 34081532; PMCID: PMC8684738.

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CCM2-deficient endothelial cells undergo a ROCK-dependent reprogramming into senescence-associated secretory phenotype

Vannier DR, Shapeti A, Chuffart F, Planus E, Manet S, Rivier P, Destaing O, Albiges-Rizo…

Angiogenesis 2021 Nov;24(4):843-860. doi: 10.1007/s10456-021-09809-2. Epub 2021 Aug 3. PMID: 34342749.

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Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage

Kerjouan A, Boyault C, Oddou C, Hiriart-Bryant E, Grichine A, Kraut A, Pezet M, Balland…

J Cell Sci. 2021 Jan 25;134(2):jcs254599. doi: 10.1242/jcs.254599. PMID: 33495358.

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Cross-talk between the calcium channel TRPV4 and reactive oxygen species interlocks adhesive and degradative functions of invadosomes

Vellino S, Oddou C, Rivier P, Boyault C, Hiriart-Bryant E, Kraut A, Martin R, Coute…

J Cell Biol 2021 Feb 1;220(2):e201910079. doi: 10.1083/jcb.201910079. PMID: 33399853; PMCID: PMC7788461.

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DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates

Glazier R, Brockman JM, Bartle E, Mattheyses AL, Destaing O*, Salaita K*

Nat Commun. 2019 Oct 18;10(1):4507. doi: 10.1038/s41467-019-12304-4. PMID: 31628308; PMCID: PMC6800454.

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LKB1 specifies neural crest cell fates through pyruvate-alanine cycling

Radu AG, Torch S, Fauvelle F, Pernet-Gallay K, Lucas A, Blervaque R, Delmas V, Schlattner…

Sci Adv 2019 Jul 17;5(7):eaau5106. doi: 10.1126/sciadv.aau5106. PMID: 31328154; PMCID: PMC6636984.

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Our collaborations

  • • National collaborations:
  • Christine Brun, TAGC Marseille : Modeling information transfer in ppin network
  • Gergo Gögl, IBV Nice : High through-put mapping of affinities of optoSFKs partners
  • Laurence Calzone, institut Curie, Paris : in silico Boolean modeling of invasive properties
  • Anita Michel-Eckly, EFS Strasbourg : Characterization of the mechanical properties of the PodoPZ in MKs invasion
  • Isabelle Bonnet, Institut Curie, Paris : Phototagging of optogenetically controlled tumor models
  • Stéphane Vassilopoulos, Inst. Myologie-Sorbonnes Université
  • Thierry Dubois, Inst. Curie-Paris, methylation signaling in cell biology and cancerology
  • Renaud Poincloux, IPBS-Toulouse, podosomes biology in macrophages
  • Claude Verdier/Pierre Recho, LIPHY Grenoble : Mechanical measurements and modeling during invasion properties
  • Claire Rome, Grenoble Neurosciences Institute: Preclinical tests in mouse models by MRI
  • • International collaborations:
  • Hans Van Oosterwyck and Susana Rocha, KU Leuven Belgium : Biomechanics and microfluidic models of CCM
  • Souvik Kar, International Neuroscience Institute, Hannover, Germany : CCM patient biobank, mechano-dependent non-coding RNAs
  • Cheng Han Yu, HKU Med-Hong-Kong: cell signaling in invadosomes