Publications :

Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis

A Casanova, G Roth, S Hausmann, X Lu, L Bischoff, E Froeliger, L Belmudes, E…

Cell Discovery 2024 Malignant forms of breast cancer refractory to existing therapies remain a major unmet health issue, primarily due to metastatic spread. A better understanding of the mechanisms at play will provide better insights for alternative treatments to prevent br

The SMYD3-MAP3K2 signaling axis promotes tumor aggressiveness and metastasis in prostate cancer

Sabeen Ikram, Apurv Rege, Maraki Y Negesse, Alexandre G Casanova, Nicolas Reynoird, Erin M Green

Science Advances 2023

SMYD3 impedes small cell lung cancer sensitivity to alkylation damage through RNF113A methylation-phosphorylation crosstalk

Lukinović V, Hausmann S, Roth GS, Oyeniran C, Ahmad T, Tsao N, Brickner JR, Casanova…

Cancer Discovery 2022 Sep 2;12(9):2158-2179. doi: 10.1158/2159-8290.CD-21-0205. PMID: 35819319

Structural insights into p300 regulation and acetylation-dependent genome organisation

Ibrahim Z, Wang T, Destaing O, Salvi N, Hoghoughi N, Chabert C, Rusu A, Gao…

Nature Communication 2022 Dec 15;13(1):7759. doi: 10.1038/s41467-022-35375-2. PMID: 36522330

Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Tsao N, Brickner JR, Rodell R, Ganguly A, Wood M, Oyeniran C, Ahmad T, Sun…

Molecular Cell. 2021 Oct 21;81(20):4228-4242.e8. doi: 10.1016/j.molcel.2021.09.024. PMID: 34686315

Lysine Methyltransferases Signaling: Histones are Just the Tip of the Iceberg

Lukinović V, Casanova AG, Roth GS, Chuffart F, Reynoird N.

Curr Protein Pept Sci 2020 21(7):655-674. doi: 10.2174/1871527319666200102101608. PMID: 31894745

Lysine methylation signaling in pancreatic cancer

Roth GS, Casanova AG, Lemonnier N, Reynoird N.

Curr Opin Oncol. 2018 2018 Jan;30(1):30-37. doi: 10.1097/CCO.0000000000000421. PMID: 29076964

Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells

Shiota H, Barral S, Buchou T, Tan M, Couté Y, Charbonnier G, Reynoird N, Boussouar…

Cell Report 2018 Sep 25;24(13):3477-3487.e6. doi: 10.1016/j.celrep.2018.08.069. PMID: 30257209

Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

Reynoird N, Mazur PK, Stellfeld T, Flores NM, Lofgren SM, Carlson SM, Brambilla E, Hainaut…

Genes Dev 2016 Apr 1;30(7):772-85. doi: 10.1101/gad.275529.115. Epub 2016 Mar 17. PMID: 26988419

Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase

Mazur PK, Gozani O, Sage J, Reynoird N.

Transl Cancer Res 2016 Jun;5(3):330-333. doi: 10.21037/tcr.2016.06.26. PMID: 30713830

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

Mazur PK, Reynoird N, Khatri P, Jansen PW, Wilkinson AW, Liu S, Barbash O, Van…

Nature 2014 Jun 12;510(7504):283-7. doi: 10.1038/nature13320. Epub 2014 May 21. PMID: 24847881