Platform
GEMELI

Grenoble Metabolomics and Lipidomics for Health

Presentation

The GEMELI platform offers services and collaborative developments in metabolomics, lipidomics and fluxomics for biomedical research and biotechnology.
GEMELI comprises 3 technical facilities combining state-of-the-art Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) equipments and the complementary expertise of the IAB and TIMC laboratories in the fields of NMR metabolomics & lipidomics (NMR facility), MS lipidomics and fluxomics (Apicolipid), and MS metabolomics (GExiM).
The platform offers expertise in the following R&D areas:

  • discovery and validation of diagnostic and predictive biomarkers for translational clinical research and precision medicine;
  • high-throughput molecular phenotyping of populations;
  • identification of target metabolic pathways, for example for the development of innovative treatments (for infectious diseases, metabolic disorders, etc.);
  • non-targeted study of cellular metabolism, metabolic fluxes and real-time quantification of metabolism, applicable in fundamental and translational research;
  • pharmaco-metabolic/lipidomic analysis in the various phases of drug development.

The development of the platform is supported by the IRICE program of the Auvergne Rhône Alpes Region.

The platform is labeled IBISA.

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Managers

Bénédicte ELENA-HERRMANN

DR CNRS, R&D Manager NMR

Cyrille BOTTÉ

DR1 CNRS, R&D Manager lipidomics

See file

Joran VILLARET

IR UGA, Operational Manager NMR

Yoshiki YAMARYO-BOTTÉ

IR UGA, Scientific and Technical Head of Lipidomics core of GEMELI platform


Centers of expertise

Our NMR facility provides a unique combination of top-of-the-art equipment and expertise in fundamental NMR methodological developments for high-throughput metabolomics applications. This axis is led by Dr. Benedicte Elena-Herrmann (IAB).

The Apicolipid facility provides a unique setup for tageted and untargeted high-throughput lipidomics & metabolite flux analysis within a dedicated P3* facility at our Jean-Roget site. This axis is led by Dr. Cyrille Botté (IAB).

The GExIM facility is a University-Hospital technological structure (UGA and CHUGA) centered on MS metabolomics for clinical research. This axis is led by Dr. Audrey Le Gouellec (TIMC).

Our major publications

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A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma.

Arnold CS, Alazzi AM, Shunmugam S, Janouškovec J, Berry L, Charital S, Gautier T, Duley…

Nature Communications 2025 Lipids are crucial for Apicomplexa survival in their human hosts. They can acquire lipids from the host cell and/or make its own in a relict non-photosynthetic and essential plastid, the apicoplast, which represents a plant-like Achilles’ Heel for the par

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Hydrogenous and deuterated phospholipid extracts from Escherichia coli as biomimetic cytoplasmic bacterial membranes.

Corucci G, Sánchez-Puga P, Batchu KC, Paracini N, Micciulla S, Laux V, Carrascosa-Tejedor J, Frewein…

Chemistry and Physics of Lipids 2025

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The antimicrobial activity of ETD151 defensin is dictated by the presence of glycosphingolipids in the targeted organisms.

Kharrat O, Yamaryo-Botté Y, Nasreddine R, Voisin S, Aumer T, Cammue BPA, Madinier JB, Knobloch…

PNAS 2024

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Developing advanced models of biological membranes with hydrogenous and deuterated natural glycerophospholipid mixtures

Corucci G, Batchu KC, Luchini A, Santamaria A, Frewein MPK, Laux V, Haertlein M, Yamaryo-Botté…

J Colloid Interface Sci 2023 Sep;645:870-881. doi: 10.1016/j.jcis.2023.04.135

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Developing advanced models of biological membranes with hydrogenous and deuterated natural glycerophospholipid mixtures.

Corucci G, Batchu KC, Luchini A, Santamaria A, Frewein MPK, Laux V, Haertlein M, Yamaryo-Botté…

Journal of Colloidal and Interface Science 2023

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Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet.

Iuso D, Garcia-Saez I, Couté Y, Yamaryo-Botté Y, Boeri Erba E, Adrait A, Zeaiter N,…

Science Advances 2023

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Investigation of circulating metabolites associated with breast cancer risk by untargeted metabolomics: a case-control study nested within the French E3N cohort

Jobard E, Dossus L, Baglietto L, Fornili M, Lécuyer L, Mancini FR, Gunter MJ, Trédan…

Br J Cancer 2021 May;124(10):1734-1743. doi: 10.1038/s41416-021-01304-1

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Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage.

Dass S, Shunmugam S, Berry L, Arnold CS, Katris NJ, Duley S, Pierrel F, Cesbron-Delauw…

Nature Communications 2021 Apicomplexan parasites require large amount of lipids that can be acquired from both host scavenging and de novo synthesis via the parasites’ own metabolic pathways. Both host and de novo synthesized lipids are essential for parasite membrane biogenesis a

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Division and Adaptation to Host Environment of Apicomplexan Parasites Depend on Apicoplast Lipid Metabolic Plasticity and Host Organelle Remodeling.

Amiar S, Katris NJ, Berry L, Dass S, Duley S, Arnold CS, Shears MJ, Brunet…

Cell Reports 2020 CNRS National Press release: https://www.insb.cnrs.fr/fr/cnrsinfo/comment-le-parasite-sadapte-la-nutrition-de-son-hote

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Fast and ergonomic extraction of adherent mammalian cells for NMR-based metabolomics studies

Mili M.; Panthu B, Madec A.-M, Berger M.-A, Rautureau G. J. P, Elena-Herrmann B

Anal. Bioanal. Chem. 2020 412, 5453. doi: 10.1007/s00216-020-02764-9.

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Our activities in pictures

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