Les publications :

A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma.

Arnold CS, Alazzi AM, Shunmugam S, Janouškovec J, Berry L, Charital S, Gautier T, Duley…

Nature Communications 2025 Lipids are crucial for Apicomplexa survival in their human hosts. They can acquire lipids from the host cell and/or make its own in a relict non-photosynthetic and essential plastid, the apicoplast, which represents a plant-like Achilles’ Heel for the par

3-Benzylmenadiones and their Heteroaromatic Analogues Target the Apicoplast of Apicomplexa Parasites: Synthesis and Bioimaging Studies.

Dupouy B, Donzel M, Roignant M, Charital S, Keumoe R, Yamaryo-Botté Y, Feckler A, Bundschuh…

ACS Infectious Diseases 2025

A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions.

Bitew MA, Paredes-Santos TC, Maru P, Krishnamurthy S, Wang Y, Sangaré LO, Duley S, Yamaryo-Botté…

Nature Communications (accepted) 2025

A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei.

Zeeshan M, Blatov I, Yanase R, Ferguson DJP, Pashley SL, Chahine Z, Yamaryo-Botté Y, Mishra…

Elife 2025

Hydrogenous and deuterated phospholipid extracts from Escherichia coli as biomimetic cytoplasmic bacterial membranes.

Corucci G, Sánchez-Puga P, Batchu KC, Paracini N, Micciulla S, Laux V, Carrascosa-Tejedor J, Frewein…

Chemistry and Physics of Lipids 2025

Long-term intermittent hypoxia in mice induces inflammatory pathways implicated in sleep apnea and steatohepatitis in humans.

Gaucher J, Montellier E, Vial G, Chuffart F, Guellerin M, Bouyon S, Lemarie E, Yamaryo-Botté…

iScience 2024

Metabolic reprogramming of hypoxic tumor-associated macrophages through CSF-1R targeting favors treatment efficiency in colorectal cancers.

Gharzeddine K, Gonzalez Prieto C, Malier M, Hennot C, Grespan R, Yamaryo-Botté Y, Botté CY,…

Journal for Immunotherapy of Cancer 2024

The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions.

Charital S, Shunmugam S, Dass S, Alazzi AM, Arnold C-S, Katris NJ, Duley S, Quansah…

mBio 2024 Lipid and fatty acid acquisition is crucial for apicomplexa survival. In this work, we identified 7 enzymes required for parasite fatty acid activation, acyl-CoA synthetases (ACS). We show that TgACS1 is crucial to allow parasite motility, and hence host

The antimicrobial activity of ETD151 defensin is dictated by the presence of glycosphingolipids in the targeted organisms.

Kharrat O, Yamaryo-Botté Y, Nasreddine R, Voisin S, Aumer T, Cammue BPA, Madinier JB, Knobloch…

PNAS 2024

Toxoplasma acyl-CoA synthetase TgACS3 is crucial to channel host fatty acids in lipid droplets and for parasite propagation.

Dass S, Shunmugam S, Charital S, Duley S, Arnold CS, Katris NJ, Cavaillès P, Cesbron-Delauw…

Journal of Lipid Research 2024

The patatin-like phospholipase PfPNPLA2 is involved in the mitochondrial degradation of phosphatidylglycerol during Plasmodium falciparum blood stage development.

Shunmugam S, Quansah N, Flammersfeld A, Islam MM, Sassmannshausen J, Bennink S, Yamaryo-Botté Y, Pradel…

Frontiers in Cellular and Infection Microbiology 2023

Variation in Lipid Species Profiles among Leukemic Cells Significantly Impacts Their Sensitivity to the Drug Targeting of Lipid Metabolism and the Prognosis of AML Patients.

Lo Presti C, Yamaryo-Botté Y, Mondet J, Berthier S, Nutiu D, Botté C, Mossuz P.

International Journal of Molecular Science 2023