Publications :

Cryptosporidium and Toxoplasma parasites are inhibited by a benzoxaborole targeting leucyl-tRNA synthetase.

*Palencia, A., Liu, RJ., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, ED., Li,…

Antimicrobial agents and chemotherapy. 2016 60(10):5817-27. doi: 10.1128/AAC.00873-16. *Corresponding Authors.

Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase

Palencia*, A., Li, X., Bu, W., Ding, C., Easom, E., Feng, et al.

Antimicrobial agents and chemotherapy 2016 60(10):6271-80

Structural characterisation of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.

Chopra, S.†, Palencia, A.†, et al.

Nature comm 2016 7:12928 †Joint-First Authors

Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism.

Zhao, H., Palencia, A., Seiradake, E., Ghaemi, Z., Cusack, S., Luthey-Schulten, Z. & Martinis, S.

ACS Chemical Biology 2015 10(10):2277-85. doi: 10.1021/acschembio.5b00291.

Structure and dynamics of the MKK7-JNK signalling complex.

Kragelj, J., Palencia, A., Nanao, MH., Maurin, D., Bouvignies, G., Blackledge, M. & Jensen, MR.

PNAS 2015 112(11):3409-14. doi: 10.1073/pnas.1419528112.

Biochemical and biophysical characterization of the Selenium binding and reducing site in Arabidopsisthaliana homologue to mammals Selenium Binding Protein 1.

Schild, F., Kieffer-Jaquinod, S., Palencia, A., Cobessi, D., et al.

Journal of Biological Chemistry 2014 289(46):31765-31776. doi: 10.1074/jbc.M114.571208.

Structure of mouse Mu-crystallin complexed with NADPH and the T3 thyroid hormone.

Borel, F., Hachi, I., Palencia, A., Gaillard, MC. & Ferrer, JL.

FEBS Journal 2014 281(6):1598-612. doi: 10.1111/febs.12726.

The physiological target for LeuRS translational quality control is norvaline.

Cvetesic, N., Palencia, A., Halasz, I., Cusack,S. & Gruic-Sovulj, I.

EMBO Journal 2014 33(15):1639-53. doi: 10.15252/embj.201488199.

The RNA-binding region of human TRBP interacts with microRNA precursors through two independent domains.

Benoit, MP., Imbert, L., Palencia, A., Perard, J., Ebel, C., Boisbouvier, J. & Plevin, MJ.

Nucleic Acids Research 2013 41(7):4241-52. doi: 10.1093/nar/gkt086.

Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.

Hernandez, V., Crépin, T., Palencia, A., Cusack, S., et al.

Antimicrobial agents and chemotherapy 2013 57(3):1394-403. doi: 10.1128/AAC.02058-12; and Research highlight in Nature 494, 151 (2013).

Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens.

Li, L., Palencia, A., Lukk, T., Li, Z., et al.

PNAS 2013 110(10):3817-22. doi: 10.1073/pnas.1218374110.

Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase

†Chopra, S., †Palencia, A., et al. 

Nature comm 2013 4, 1417. †Joint-First Authors.