Les publications :

 Aminoacyl-tRNA synthetases as drug targets.

Lukarska, M. & *Palencia, A.

The Enzymes, Elsevier 2020 48:321-350. 10.1016/bs.enz.2020.07.001.

Binding site plasticity in viral PPxY Late domain recognition by the third WW domain of human NEDD4.

Iglesias-Bexiga, M., Palencia, A., Corbi-Verge, C., Martin-Malpartida, P., Blanco, FJ., Macias, MJ., Cobos, ES. &…

  Scientific Reports 2019 9(1):15076. doi: 10.1038/s41598-019-50701-3.

Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection

Swale, C., Bougdour, A., Gnahoui-David, A., Tottey, J., Georgeault, S., *Laurent,  F., *†Palencia, A.  *†Hakimi, M.A.

Science Trans. Medicine 2019 6;11(517). †Equally contributing authors

Deciphering the Dynamic Interaction Profile of an Intrinsically Disordered Protein by NMR Exchange Spectroscopy.

Delaforge, E., Kragelj, J., Tengo, L., Palencia, A., Milles, S., Bouvignies, G., Salvi, N., Blackledge,…

Journal of The American Chemical Society 2018 140(3):1148-1158. doi: 10.1021/jacs.7b12407.

Kinetic origin of substrate specificity in post-transfer editing by leucyl-tRNA synthetase.

Dulic, M., Cvetesic, N., Zivkovic, I., Palencia, A., Cusack, S., Bertosa, B. & Gruic-Sovulj, I.

Journal of Molecular Biology 2018 430(1):1-16. doi: 10.1016/j.jmb.2017.10.024.

Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites.

Sindikubwabo, F., Ding, S., Hussain, T., Ortet, P., Barakat, M., Baumgarten, S., Cannella, D., Palencia,…

Elife 2017 6:e29391. doi: 10.7554/eLife.29391.

Structural basis for the subversion of MAP kinase signalling by an intrinsically disordered parasite secreted agonist.

Pellegrini, E., Palencia, A., Braun, L., Kapp, U., Bougdour, A., Belrhali, H., Bowler, MW. et al.

Structure 2017 25(1):16-26. doi: 10.1016/j.str.2016.10.011.

Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis

*†Palencia, A., †*Bougdour, A., Brenier-Pinchart, MP., Touquet, B., Bertini, RL., Sensi, C. et al. 

EMBO Molecular Medicine 2017 9: 385-394 . Highlighted in  France 3 news. *Corresponding Authors.

Aminoacetylation reaction catalyzed by leucyl-tRNA synthetase operates via a self-assisted mechanism using a conserved residue and the aminoacyl substrate.

Aleksandrov, A., Palencia, A., Cusack, S. & Field, M.

Journal of Physical Chemistry B 2016 120(19):4388-98. doi: 10.1021/acs.jpcb.6b02387.

Anti-malarial benzoxaboroles target P. falciparum leucyl-tRNA synthetase.

Sonoiki, E., Palencia, A., Guo, D., Ahyong, V., Dong, C., Li, X., Hernandez, V., Zhang,…

Antimicrobial agents and chemotherapy 2016 60(8):4886-95. doi: 10.1128/AAC.00820-16.

Cryptosporidium and Toxoplasma parasites are inhibited by a benzoxaborole targeting leucyl-tRNA synthetase.

*Palencia, A., Liu, RJ., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, ED., Li,…

Antimicrobial agents and chemotherapy. 2016 60(10):5817-27. doi: 10.1128/AAC.00873-16. *Corresponding Authors.

Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase

Palencia*, A., Li, X., Bu, W., Ding, C., Easom, E., Feng, et al.

Antimicrobial agents and chemotherapy 2016 60(10):6271-80