Publications :

In vivo vectorization and delivery systems for gene therapies and RNA-based therapeutics in oncology

Schock Vaiani, J. Broekgaarden, M. Coll, J. L. Sancey, L. Busser, B.

Nanoscale 2025 Gene and RNA-based therapeutics represent a promising frontier in oncology, enabling targeted modulation of tumor-associated genes and proteins. This review explores the latest advances in payload vectorization and delivery systems developed for in vivo c

Engineering Radiocatalytic Nanoliposomes with Hydrophobic Gold Nanoclusters for Radiotherapy Enhancement

Carigga Gutierrez, N. M. Clainche, T. L. Bulin, A. L. Leo, S. Kadri, M. Abdelhamid,…

Adv Mater 2024 Chemoradiation therapy is on the forefront of pancreatic cancer care, and there is a continued effort to improve its safety and efficacy. Liposomes are widely used to improve chemotherapy safety, and may accurately deliver high-Z element- radiocatalytic n

Enhanced CRISPR-Cas9 RNA system delivery using cell penetrating peptides-based nanoparticles for efficient in vitro and in vivo applications

Guzman Gonzalez, V. Grunenberger, A. Nicoud, O. Czuba, E. Vollaire, J. Josserand, V. Le Guevel,…

J Control Release 2024 CRISPR-Cas9 system has emerged as a revolutionary gene-editing tool with huge therapeutic potential for addressing the underlying genetic causes of various diseases, including cancer. However, there are challenges such as the delivery method that must be

Nanoscintillator Coating: A Key Parameter That Strongly Impacts Internalization, Biocompatibility, and Therapeutic Efficacy in Pancreatic Cancer Models

Aubrun Fulbert, Clémentine Chaput, Frédéric Stelse‐Masson, Sarah Henry, Maxime Chovelon, Benoit Bohic, Sylvain Brueckner, Dennis…

Small Science 2024 Pancreatic cancer is associated with a poor prognosis despite multimodal treatments. To improve the efficacy of radiotherapy, the use of nanoscintillators is emerging. Made of high-Z elements, they absorb X-rays more efficiently than tissues and can local

Quantifying Titanium Exposure in Lung Tissues: A Novel Laser‐Induced Breakdown Spectroscopy Elemental Imaging‐Based Analytical Framework for Biomedical Application

Gardette, V. Sancey, L. Leprince, M. Gaté, L. Cosnier, F. Seidel, C. Valentino, S. Pelascini,…

Small Science 2024 Occupational and environmental exposures, particularly those related to urban and suburban atmospheres, are increasingly linked to a range of pulmonary diseases. While diagnostic methods for these diseases are well established, analytical tools for assess

Self-assembled peptide-gold nanoclusters with siRNA targeting telomeric response to enhance radiosensitivity in lung cancer cells.

Moro, S. Omrani, M. Erbek, S. Jourdan, M. Vandekerckhove, V. I. Nogier, C. Vanwonterghem, L…

Small Science 2024 Lung cancer cells resistant to radiotherapy present a significant clinical challenge. Stable telomeric structures, maintained by the TRF2 protein, play a critical role in protecting cells from ionizing radiation. Reduced TRF2 expression increases DNA dama

Serum IGF1 Is a Prognostic Marker for Resistance to Targeted Therapies and a Predictive Marker for Anti-IGF1 Receptor Therapy in Melanoma

Castillo-Ferrer, C. Marguet, T. Vanwonterghem, L. Erbek, S. Chuffart, F. Mouret, S. Messai, S. T.…

J Invest Dermatol 2024 Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenoble Alpes University, Grenoble, France; Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France. Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenobl

3D-Printed Osteoinductive Polymeric Scaffolds with Optimized Architecture to Repair a Sheep Metatarsal Critical-Size Bone Defect

Garot, C. Schoffit, S. Monfoulet, C. Machillot, P. Deroy, C. Roques, S. Vial, J. Vollaire,…

Adv Healthc Mater 2023 The reconstruction of critical-size bone defects in long bones remains a challenge for clinicians. A new osteoinductive medical device is developed here for long bone repair by combining a 3D-printed architectured cylindrical scaffold made of clinical-gra

Lipoprotein interactions with water-soluble NIR-II emitting aza-BODIPYs boost the fluorescence signal and favor selective tumor targeting

Kalot, G., Godard, A., Busser, B., Bendellaa, M., Dalonneau, F., Paul, C., Le Guével, X.,…

Biomater Sci 2022

Tailoring the SWIR emission of gold nanoclusters by surface ligand rigidification and their application in 3D bioimaging

Le Guevel, X., Wegner, K. D., Wurth, C., Baulin, V. A., Musnier, B., Josserand, V.,…

Chemical communications 2022 58, 2967-2970

High-Resolution Shortwave Infrared Imaging of Vascular Disorders Using Gold Nanocluster

Yu, Z., Musnier, B., Wegner, K. D., Henry, M., Chovelon, B., Desroches-Castan, A., Fertin, A.,…

ACS Nano 2020 14, 4973-4981

Mechano-Bactericidal Titanium Surfaces for Bone Tissue Engineering

Clainche, T. L., Linklater, D., Wong, S., Le, P., Juodkazis, S., Guevel, X. L., Coll,…

ACS Appl Mater Interfaces 2020 12, 48272-48283