Les publications

A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma.

Arnold CS, Alazzi AM, Shunmugam S, Janouškovec J, Berry L, Charital S, Gautier T, Duley…

Nature Communications 2025 Lipids are crucial for Apicomplexa survival in their human hosts. They can acquire lipids from the host cell and/or make its own in a relict non-photosynthetic and essential plastid, the apicoplast, which represents a plant-like Achilles’ Heel for the par

Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential

Wei K. et al.

Advanced Science 2025 The fungal Bromodomain and Extra-Terminal (BET) protein Bdf1 is a potential antifungal target against invasive fungal infections. However, the need to selectively inhibit both Bdf1 bromodomains (BDs) over human orthologs and the lack of molecular tools to

Personal exposure to air pollutants and immune system biomarkers in pregnant women

Marsal A, Frau L, Chaperot L, Amine I, Lyon-Caen S, Boudier A, Jaffrezo JL, Elazzouzi…

Sci Rep. 2025 May 21;15(1):17672. doi: 10.1038/s41598-025-98712-7. PMID: 40399383; PMCID: PMC12095663.

SRSF2 overexpression induces transcription-/replication-dependent DNA double-strand breaks and interferes with DNA repair pathways to promote lung tumor progression

Khalife M, Jia T, Caron P, Shreim A, Genoux A, Cristini A, Pucciarelli A, Leverve…

NAR Cancer. 2025 Apr 2;7(2):zcaf011. doi: 10.1093/narcan/zcaf011. PMID: 40181846; PMCID: PMC11963763.

Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis

A Casanova, G Roth, S Hausmann, X Lu, L Bischoff, E Froeliger, L Belmudes, E…

Cell Discovery 2024

Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption

Caroline Nava; Benjamin Cogne; Amandine Santini; Elsa Leitão; François Lecoquierre; Yuyang Chen; Sarah L. Stenton;…

Nature Genetics 2024

ECT2 peptide sequences outside the YTH domain regulate its m6A-RNA binding

Seigneurin-Berny D, Karczewski C, Delaforge E, Yaacoub K, Gaspar Litholdo C Jr, Favory JJ, Ringkjøbing…

RNA Biol. 2024 Jan.

Engineering Radiocatalytic Nanoliposomes with Hydrophobic Gold Nanoclusters for Radiotherapy Enhancement

Carigga Gutierrez, N. M. Clainche, T. L. Bulin, A. L. Leo, S. Kadri, M. Abdelhamid,…

Adv Mater 2024 Chemoradiation therapy is on the forefront of pancreatic cancer care, and there is a continued effort to improve its safety and efficacy. Liposomes are widely used to improve chemotherapy safety, and may accurately deliver high-Z element- radiocatalytic n

Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth

Shapeti A, Barrasa-Fano J, Abdel Fattah AR, de Jong J, Sanz-Herrera JA, Pezet M, Assou…

Nat Commun. 2024 Oct 6;15(1):8660. doi: 10.1038/s41467-024-52866-6. PMID: 39370485; PMCID: PMC11456588.

In vitro production of cat-restricted Toxoplasma pre-sexual stages

Ana Vera Antunes, Martina Shahinas, Christopher Swale, Dayana C. Farhat, Chandra Ramakrishnan, Christophe Bruley, Dominique…

Nature 2024 These authors contributed equally: Ana Vera Antunes, Martina Shahinas, Christopher Swale

Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse

Muroňová J, Kherraf ZE, Giordani E, Lambert E, Eckert S, Cazin C, Amiri-Yekta A, Court…

Elife 2024

Nanoscintillator Coating: A Key Parameter That Strongly Impacts Internalization, Biocompatibility, and Therapeutic Efficacy in Pancreatic Cancer Models

Aubrun Fulbert, Clémentine Chaput, Frédéric Stelse‐Masson, Sarah Henry, Maxime Chovelon, Benoit Bohic, Sylvain Brueckner, Dennis…

Small Science 2024 Pancreatic cancer is associated with a poor prognosis despite multimodal treatments. To improve the efficacy of radiotherapy, the use of nanoscintillators is emerging. Made of high-Z elements, they absorb X-rays more efficiently than tissues and can local

WazaGaY: An Innovative Aza-BODIPY-Derived Near-Infrared Fluorescent Probe for Enhanced Tumor Imaging

Bendellaa M, Cave C, Godard A, Dalonneau F, Sickinger A, Goze C, Maury O, Le…

J Med Chem 2024 Sep 26;67(18):16635-16648. doi: 10.1021/acs.jmedchem.4c01435. Epub 2024 Sep 17. PMID: 39289797.

The fate of mitochondria during platelet activation.

Grichine A, Jacob SP, Eckly AE, Villaret J, Joubert C, Appaix F, Pezet M, Ribba…

Blood Adv. 2023 Oct 24;7(20):6290-6302. doi: 10.1182/bloodadvances.2023010423. PMID: 37624769; PMCID: PMC10589785. 2023