Institut pour
l’Avancée des Biosciences

A comprehensive study of the sperm head defects in MMAF condition and their impact on embryo development in mice

Jana Muroňová, Emeline Lambert, Chanyuth Thamwan, Zeina Wehbe, Magali Court, Geneviève Chevalier, Jessica Escoffier, Zine-Eddine…

Molecular Humain Reproduction 2025

A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma

Arnold CS et aL.

Nat Commun 2025 Toxoplasma gondii, an apicomplexan parasite and agent of the human disease toxoplasmosis, possesses a non-photosynthetic relic plastid, named the apicoplast. Thought to be evolved from a red algal plastid, the apicoplast houses major metabolic pathways, s

A recurrent loss-of-function variant in DRC1 causes non-syndromic severe asthenozoospermia with favorable intracytoplasmic sperm injection and pregnancy outcomes

Célia Tebbakh, Anne-Laure Barbotin, Guillaume Martinez, Angèle Boursier, Zeina Wehbe, Asma Hammouda, Nicolas Thierry-Mieg, Christophe…

Andrology 2025

A recurrent ZP1 variant is responsible for oocyte maturation defect with degenerated oocytes in infertile females

Corinne Loeuillet, Magali Dhellemmes, Caroline Cazin, Zine-Eddine Kherraf, Selima Fourati Ben Mustapha, Raoudha Zouari, Nicolas…

Clinical Genetics 2025

Bipartite binding of the intrinsically disordered scaffold protein JIP1 to the kinase JNK1.

Orand, T., Delaforge, E., Lee, A., Kragelj, J., Davis, RJ., Palencia, A.*, Jensen, MR.*

Proceedings of the National Academy of Sciences of USA. 2025

Combined physical and biological contributions to radiotherapy enhancement by Lu-based nanoscintillators in pancreatic cancer models.

Stelse-Masson, S., Lytvynenko, X., Bedregal-Portugal, K., Aubrun, C., Lavaud, M., Kadri, M., Jacquet, T., Moriscot,…

Nanotheranostics 2025 Methods: In this paper, we study the ability of Lu 3 Al 5 O 12: Pr@ SiO 2, a lutetium-based nanoscintillator, to exert a radiation dose-enhancement effect in two human pancreatic cancer cell models, namely PANC-1 and MIA PaCa-2. Results: Lu 3 Al 5 O 12:

Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption.

Nava C, … Charbonnier C, Charenton C, Thevenon J, Depienne C

Nat Genet. 2025 Jun;57(6):1374-1388. doi: 10.1038/s41588-025-02184-4. Epub 2025 May 16. PMID: 40379786; PMCID: PMC12165858.

Homozygous deleterious variants in MYCBPAP induce asthenoteratozoospermia involving abnormal acrosome biogenesis, manchette structure and sperm tail assembly in humans and mice

Yiling Zhou, Chaofeng Tu, Charles Coutton, Jianan Tang, Shixiong Tian, Shuyan Tang, Guillaume Martinez, Dapeng…

Science China Life Science 2025

Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential

Wei K. et al.

Advanced Science 2025 The fungal Bromodomain and Extra-Terminal (BET) protein Bdf1 is a potential antifungal target against invasive fungal infections. However, the need to selectively inhibit both Bdf1 bromodomains (BDs) over human orthologs and the lack of molecular tools to

In vivo vectorization and delivery systems for gene therapies and RNA-based therapeutics in oncology

Schock Vaiani, J. Broekgaarden, M. Coll, J. L. Sancey, L. Busser, B.

Nanoscale 2025 Gene and RNA-based therapeutics represent a promising frontier in oncology, enabling targeted modulation of tumor-associated genes and proteins. This review explores the latest advances in payload vectorization and delivery systems developed for in vivo c