Les publications :

Combined physical and biological contributions to radiotherapy enhancement by Lu-based nanoscintillators in pancreatic cancer models.

Stelse-Masson, S., Lytvynenko, X., Bedregal-Portugal, K., Aubrun, C., Lavaud, M., Kadri, M., Jacquet, T., Moriscot,…

Nanotheranostics 2025 Methods: In this paper, we study the ability of Lu 3 Al 5 O 12: Pr@ SiO 2, a lutetium-based nanoscintillator, to exert a radiation dose-enhancement effect in two human pancreatic cancer cell models, namely PANC-1 and MIA PaCa-2. Results: Lu 3 Al 5 O 12:

In vivo vectorization and delivery systems for gene therapies and RNA-based therapeutics in oncology

Schock Vaiani, J. Broekgaarden, M. Coll, J. L. Sancey, L. Busser, B.

Nanoscale 2025 Gene and RNA-based therapeutics represent a promising frontier in oncology, enabling targeted modulation of tumor-associated genes and proteins. This review explores the latest advances in payload vectorization and delivery systems developed for in vivo c

Monomer Versus Dimer of Cationic Ir(III) Complexes for Photodynamic Therapy by Two-Photon Activation: A Comparative Study.

Barta, A., Vanwonterghem, L., Lavaud, M., Molton, F., Micouin, G., Bulin, A. L., Banyasz, A.,…

ACS Appl Bio Mater 2025 Iridium(III) complexes have been recognized as promising candidates for two-photon sensitized photodynamic therapy (PDT). In this context, we report on the study of two complexes: a monomer (IrL(1)) and a dimer (Ir(2)L(2)). Both complexes possess 2-phenyl

Multifunctional micro/nano-textured titanium with bactericidal, osteogenic, angiogenic and anti-inflammatory properties: Insights from in vitro and in vivo studies

Ziegelmeyer, T. Martins de Sousa, K. Liao, T. Y. Lartizien, R. Delay, A. Vollaire, J.…

Mater Today Bio 2025 Titanium (Ti) is widely used as an implantable material for bone repair in orthopedics and dentistry. However, Ti implants are vulnerable to bacterial infections, which can compromise patient recovery and lead to implant failure. While a controlled inflam

Self-Assembled Peptide-Gold Nanoclusters with SiRNA Targeting Telomeric Response to Enhance Radiosensitivity in Lung Cancer Cells

Moro, S., Omrani, M., Erbek, S., Jourdan, M., Vandekerckhove, C. I., Nogier, C., Vanwonterghem, L.,…

Small Science 2025 Lung cancer cells resistant to radiotherapy present a significant clinical challenge. Stable telomeric structures, maintained by the TRF2 protein, play a critical role in protecting cells from ionizing radiation. Reduced TRF2 expression increases DNA dama

The physicochemical and biochemical mechanisms of porphyrinoid-mediated radiodynamic therapy.

Leo, S., Carigga Gutierrez, N. M., Bulin, A. L., Coll, J. L., Sancey, L., Habermeyer,…

Eur J Med Chem 2025 Radiotherapy is the standard treatment for nearly 60 % of cancer patients. Despite advancements such as brachytherapy, stereotactic radiotherapy, and intensity-modulated radiotherapy, further improvements in efficacy and safety are needed. Radiodynamic th

Engineering Radiocatalytic Nanoliposomes with Hydrophobic Gold Nanoclusters for Radiotherapy Enhancement

Carigga Gutierrez, N. M. Clainche, T. L. Bulin, A. L. Leo, S. Kadri, M. Abdelhamid,…

Adv Mater 2024 Chemoradiation therapy is on the forefront of pancreatic cancer care, and there is a continued effort to improve its safety and efficacy. Liposomes are widely used to improve chemotherapy safety, and may accurately deliver high-Z element- radiocatalytic n

Enhanced CRISPR-Cas9 RNA system delivery using cell penetrating peptides-based nanoparticles for efficient in vitro and in vivo applications

Guzman Gonzalez, V. Grunenberger, A. Nicoud, O. Czuba, E. Vollaire, J. Josserand, V. Le Guevel,…

J Control Release 2024 CRISPR-Cas9 system has emerged as a revolutionary gene-editing tool with huge therapeutic potential for addressing the underlying genetic causes of various diseases, including cancer. However, there are challenges such as the delivery method that must be

Nanoscintillator Coating: A Key Parameter That Strongly Impacts Internalization, Biocompatibility, and Therapeutic Efficacy in Pancreatic Cancer Models

Aubrun Fulbert, Clémentine Chaput, Frédéric Stelse‐Masson, Sarah Henry, Maxime Chovelon, Benoit Bohic, Sylvain Brueckner, Dennis…

Small Science 2024 Pancreatic cancer is associated with a poor prognosis despite multimodal treatments. To improve the efficacy of radiotherapy, the use of nanoscintillators is emerging. Made of high-Z elements, they absorb X-rays more efficiently than tissues and can local

Quantifying Titanium Exposure in Lung Tissues: A Novel Laser‐Induced Breakdown Spectroscopy Elemental Imaging‐Based Analytical Framework for Biomedical Application

Gardette, V. Sancey, L. Leprince, M. Gaté, L. Cosnier, F. Seidel, C. Valentino, S. Pelascini,…

Small Science 2024 Occupational and environmental exposures, particularly those related to urban and suburban atmospheres, are increasingly linked to a range of pulmonary diseases. While diagnostic methods for these diseases are well established, analytical tools for assess

Roles of zinc in cancers: From altered metabolism to therapeutic applications

Bendellaa, M. Lelievre, P. Coll, J. L. Sancey, L. Deniaud, A. Busser, B.

Int J Cancer 2024 Zinc (Zn) is a crucial trace element involved in various cellular processes, including oxidative stress, apoptosis and immune response, contributing to cellular homeostasis. Dysregulation of Zn homeostasis occurs in certain cancers. This review discusses

Serum IGF1 Is a Prognostic Marker for Resistance to Targeted Therapies and a Predictive Marker for Anti-IGF1 Receptor Therapy in Melanoma

Castillo-Ferrer, C. Marguet, T. Vanwonterghem, L. Erbek, S. Chuffart, F. Mouret, S. Messai, S. T.…

J Invest Dermatol 2024 Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenoble Alpes University, Grenoble, France; Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France. Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenobl