Les publications :

The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions.

Charital S, Shunmugam S, Dass S, Alazzi AM, Arnold C-S, Katris NJ, Duley S, Quansah…

mBio 2024 Lipid and fatty acid acquisition is crucial for apicomplexa survival. In this work, we identified 7 enzymes required for parasite fatty acid activation, acyl-CoA synthetases (ACS). We show that TgACS1 is crucial to allow parasite motility, and hence host

The antimicrobial activity of ETD151 defensin is dictated by the presence of glycosphingolipids in the targeted organisms.

Kharrat O, Yamaryo-Botté Y, Nasreddine R, Voisin S, Aumer T, Cammue BPA, Madinier JB, Knobloch…

PNAS 2024

Toxoplasma acyl-CoA synthetase TgACS3 is crucial to channel host fatty acids in lipid droplets and for parasite propagation.

Dass S, Shunmugam S, Charital S, Duley S, Arnold CS, Katris NJ, Cavaillès P, Cesbron-Delauw…

Journal of Lipid Research 2024

The patatin-like phospholipase PfPNPLA2 is involved in the mitochondrial degradation of phosphatidylglycerol during Plasmodium falciparum blood stage development.

Shunmugam S, Quansah N, Flammersfeld A, Islam MM, Sassmannshausen J, Bennink S, Yamaryo-Botté Y, Pradel…

Frontiers in Cellular and Infection Microbiology 2023

Variation in Lipid Species Profiles among Leukemic Cells Significantly Impacts Their Sensitivity to the Drug Targeting of Lipid Metabolism and the Prognosis of AML Patients.

Lo Presti C, Yamaryo-Botté Y, Mondet J, Berthier S, Nutiu D, Botté C, Mossuz P.

International Journal of Molecular Science 2023

A Plasmodium falciparum lysophospholipase regulates host fatty acid flux via parasite lipid storage to enable controlled asexual schizogony.

Sheokand PK, Yamaryo-Botté Y, Narwal M, Arnold CS, Thakur V, Islam MM, Banday MM, Asad…

Cell Reports 2023 FRM Press release : https://www.frm.org/recherches-maladies-infectieuses/paludisme/decouverte-de-candidats-medicaments-prometteurs CNRS Press release : https://www.insb.cnrs.fr/fr/cnrsinfo/comment-tuer-le-parasite-de-la-malaria-paludisme-en-le-rendant-ob

CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells.

Krishnamurthy S, Maru P, Wang Y, Bitew MA, Mukhopadhyay D, Yamaryo-Botté Y, Paredes-Santos TC, Sangaré…

mBio 2023

Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet.

Iuso D, Garcia-Saez I, Couté Y, Yamaryo-Botté Y, Boeri Erba E, Adrait A, Zeaiter N,…

Science Advances 2023

Fatty Acid Profiles of Leishmania major Derived from Human and Rodent Hosts in Endemic Cutaneous Leishmaniasis Areas of Tunisia and Algeria.

Bouabid C, Yamaryo-Botté Y, Rabhi S, Bichiou H, Hkimi C, Bouglita W, Chaouach M, Eddaikra…

Pathogens 2022

A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in calcium-induced Toxoplasma gondii egress.

Nofal SD, Dominicus C, Broncel M, Katris NJ, Flynn HR, Arrizabalaga G, Botté CY, Invergo…

Plos Pathogens 2022

Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability.

Renaud EA, Pamukcu S, Cerutti A, Berry L, Lemaire-Vieille C, Yamaryo-Botté Y, Botté CY, Besteiro…

Journal of Biological Chemistry 2022

PI4-kinase and PfCDPK7 signaling regulate phospholipid biosynthesis in Plasmodium falciparum.

Maurya R, Tripathi A, Kumar M, Antil N, Yamaryo-Botté Y, Kumar P, Bansal P, Doerig…

EMBO Reports 2022 Manipulation, recycling and reassembly of host and existing lipids is vital for parasite lipid homeostasis. This requires both regulating mechanisms and metabolic effectors to do the job. We identified a plant-like Calcium dependent kinase (CDPK7) as bein