Adenosine Dependent Activation Mechanism of Prodrugs Targeting an Aminoacyl-tRNA Synthetase
Hoffmann, G., Le Gorrec, M., Mestdach, E., Cusack, S., Salmon, L., *Jensen, MR. & *Palencia,…
Journal of The American Chemical Society 2023 145(2), 800-810. *Corresponding authors
Human Histone pre-mRNA Assembles Histone- or Canonical-mRNA Processing Complexes by Overlapping 3’-End Sequence Elements
Ielasi, F.S., Ternifi, S., Fontaine, E., Iuso, D., Couté, Y. & *Palencia A.
Nucleic Acids Research 2022 28; 50 (21):12425-12443
Visualizing protein breathing motions associated with aromatic ring flipping
Mariño Perez, L., Ielasi, FS., Bessa, LM., Maurin, D., Kragelj, J., Blackledge, M., Salvi, N.,…
Nature 2022 602, 695-700. *Corresponding authors
Aminoacyl-tRNA synthetases as drug targets
Lukarska, M. & *Palencia, A.
The Enzymes, Elsevier. 2020 48:321-350
Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection
Swale, C., Bougdour, A., Gnahoui-David, A., Tottey, J., Georgeault, S., *Laurent, F., *†Palencia, A. *†Hakimi, M.A.
Science Trans. Medicine 2019 6;11(517). †Equally contributing authors
Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis
*†Palencia, A., †*Bougdour, A., et al.
EMBO Molecular Medicine 2017 9: 385-394 . Highlighted in France 3 news. *Corresponding Authors.
Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase
Palencia*, A., Li, X., Bu, W., Ding, C., Easom, E., Feng, et al.
Antimicrobial agents and chemotherapy 2016 60(10):6271-80
Structural characterisation of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.
Chopra, S.†, Palencia, A.†, et al.
Nature comm 2016 7:12928 †Joint-First Authors
Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase
†Chopra, S., †Palencia, A., et al.
Nature comm 2013 4, 1417. †Joint-First Authors.
Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase
Palencia, A., Crepin, T., et al.
Nature Struct. & Mol. Biol 2012 19, 677-84.