Les publications :

Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase

Palencia*, A., Li, X., Bu, W., Ding, C., Easom, E., Feng, et al.

Antimicrobial agents and chemotherapy 2016 60(10):6271-80

Structural characterisation of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.

Chopra, S.†, Palencia, A.†, et al.

Nature comm 2016 7:12928 †Joint-First Authors

Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism.

Zhao, H., Palencia, A., Seiradake, E., Ghaemi, Z., Cusack, S., Luthey-Schulten, Z. & Martinis, S.

ACS Chemical Biology 2015 10(10):2277-85. doi: 10.1021/acschembio.5b00291.

Structure and dynamics of the MKK7-JNK signalling complex.

Kragelj, J., Palencia, A., Nanao, MH., Maurin, D., Bouvignies, G., Blackledge, M. & Jensen, MR.

PNAS 2015 112(11):3409-14. doi: 10.1073/pnas.1419528112.

Biochemical and biophysical characterization of the Selenium binding and reducing site in Arabidopsisthaliana homologue to mammals Selenium Binding Protein 1.

Schild, F., Kieffer-Jaquinod, S., Palencia, A., Cobessi, D., et al.

Journal of Biological Chemistry 2014 289(46):31765-31776. doi: 10.1074/jbc.M114.571208.

Structure of mouse Mu-crystallin complexed with NADPH and the T3 thyroid hormone.

Borel, F., Hachi, I., Palencia, A., Gaillard, MC. & Ferrer, JL.

FEBS Journal 2014 281(6):1598-612. doi: 10.1111/febs.12726.

The physiological target for LeuRS translational quality control is norvaline.

Cvetesic, N., Palencia, A., Halasz, I., Cusack,S. & Gruic-Sovulj, I.

EMBO Journal 2014 33(15):1639-53. doi: 10.15252/embj.201488199.

The RNA-binding region of human TRBP interacts with microRNA precursors through two independent domains.

Benoit, MP., Imbert, L., Palencia, A., Perard, J., Ebel, C., Boisbouvier, J. & Plevin, MJ.

Nucleic Acids Research 2013 41(7):4241-52. doi: 10.1093/nar/gkt086.

Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.

Hernandez, V., Crépin, T., Palencia, A., Cusack, S., et al.

Antimicrobial agents and chemotherapy 2013 57(3):1394-403. doi: 10.1128/AAC.02058-12; and Research highlight in Nature 494, 151 (2013).

Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens.

Li, L., Palencia, A., Lukk, T., Li, Z., et al.

PNAS 2013 110(10):3817-22. doi: 10.1073/pnas.1218374110.

Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase

†Chopra, S., †Palencia, A., et al. 

Nature comm 2013 4, 1417. †Joint-First Authors.

A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing.

Xiol, J. Cora E., Koglgrubel, R., Chuma, S., Subramanian, S., Hosakawa, M., Reuter, M., Yang,…

Molecular cell 2012 47(6):970-9. doi: 10.1016/j.molcel.2012.07.019.