Les publications :

Shaping NIR-II Emission: The Role of Surface Chemistry and Environment in Gold Nanoclusters

X. Le Guével

Acc Chem Res 2025

The physicochemical and biochemical mechanisms of porphyrinoid-mediated radiodynamic therapy.

Leo, S., Carigga Gutierrez, N. M., Bulin, A. L., Coll, J. L., Sancey, L., Habermeyer,…

Eur J Med Chem 2025 Radiotherapy is the standard treatment for nearly 60 % of cancer patients. Despite advancements such as brachytherapy, stereotactic radiotherapy, and intensity-modulated radiotherapy, further improvements in efficacy and safety are needed. Radiodynamic th

Tunable NIR-II photoluminescence in peptidic gold nanoclusters dynamic covalent polymerization

F. Rezak, J. Coll, G. Dubacheva, F. Loiseau, S. Ulrich, X. Le Guével

Chem Commun (Camb) 2025

Engineering Radiocatalytic Nanoliposomes with Hydrophobic Gold Nanoclusters for Radiotherapy Enhancement

Carigga Gutierrez, N. M. Clainche, T. L. Bulin, A. L. Leo, S. Kadri, M. Abdelhamid,…

Adv Mater 2024 Chemoradiation therapy is on the forefront of pancreatic cancer care, and there is a continued effort to improve its safety and efficacy. Liposomes are widely used to improve chemotherapy safety, and may accurately deliver high-Z element- radiocatalytic n

Enhanced CRISPR-Cas9 RNA system delivery using cell penetrating peptides-based nanoparticles for efficient in vitro and in vivo applications

Guzman Gonzalez, V. Grunenberger, A. Nicoud, O. Czuba, E. Vollaire, J. Josserand, V. Le Guevel,…

J Control Release 2024 CRISPR-Cas9 system has emerged as a revolutionary gene-editing tool with huge therapeutic potential for addressing the underlying genetic causes of various diseases, including cancer. However, there are challenges such as the delivery method that must be

Nanoscintillator Coating: A Key Parameter That Strongly Impacts Internalization, Biocompatibility, and Therapeutic Efficacy in Pancreatic Cancer Models

Aubrun Fulbert, Clémentine Chaput, Frédéric Stelse‐Masson, Sarah Henry, Maxime Chovelon, Benoit Bohic, Sylvain Brueckner, Dennis…

Small Science 2024 Pancreatic cancer is associated with a poor prognosis despite multimodal treatments. To improve the efficacy of radiotherapy, the use of nanoscintillators is emerging. Made of high-Z elements, they absorb X-rays more efficiently than tissues and can local

Quantifying Titanium Exposure in Lung Tissues: A Novel Laser‐Induced Breakdown Spectroscopy Elemental Imaging‐Based Analytical Framework for Biomedical Application

Gardette, V. Sancey, L. Leprince, M. Gaté, L. Cosnier, F. Seidel, C. Valentino, S. Pelascini,…

Small Science 2024 Occupational and environmental exposures, particularly those related to urban and suburban atmospheres, are increasingly linked to a range of pulmonary diseases. While diagnostic methods for these diseases are well established, analytical tools for assess

Roles of zinc in cancers: From altered metabolism to therapeutic applications

Bendellaa, M. Lelievre, P. Coll, J. L. Sancey, L. Deniaud, A. Busser, B.

Int J Cancer 2024 Zinc (Zn) is a crucial trace element involved in various cellular processes, including oxidative stress, apoptosis and immune response, contributing to cellular homeostasis. Dysregulation of Zn homeostasis occurs in certain cancers. This review discusses

Serum IGF1 Is a Prognostic Marker for Resistance to Targeted Therapies and a Predictive Marker for Anti-IGF1 Receptor Therapy in Melanoma

Castillo-Ferrer, C. Marguet, T. Vanwonterghem, L. Erbek, S. Chuffart, F. Mouret, S. Messai, S. T.…

J Invest Dermatol 2024 Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenoble Alpes University, Grenoble, France; Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France. Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenobl

WazaGaY: An Innovative Aza-BODIPY-Derived Near-Infrared Fluorescent Probe for Enhanced Tumor Imaging

Bendellaa M, Cave C, Godard A, Dalonneau F, Sickinger A, Goze C, Maury O, Le…

J Med Chem 2024 Sep 26;67(18):16635-16648. doi: 10.1021/acs.jmedchem.4c01435. Epub 2024 Sep 17. PMID: 39289797.

3D-Printed Osteoinductive Polymeric Scaffolds with Optimized Architecture to Repair a Sheep Metatarsal Critical-Size Bone Defect

Garot, C. Schoffit, S. Monfoulet, C. Machillot, P. Deroy, C. Roques, S. Vial, J. Vollaire,…

Adv Healthc Mater 2023 The reconstruction of critical-size bone defects in long bones remains a challenge for clinicians. A new osteoinductive medical device is developed here for long bone repair by combining a 3D-printed architectured cylindrical scaffold made of clinical-gra

NIR-II Aza-BODIPY Dyes Bioconjugated to Monoclonal Antibody Trastuzumab for Selective Imaging of HER2-Positive Ovarian Cancer.

Godard, A., Kalot, G., Privat, M., Bendellaa, M., Busser, B., Wegner, K. D., Denat, F.,…

J Med Chem 2023 Using fluorescence-guided surgery (FGS) to cytoreductive surgery helps achieving complete resection of microscopic ovarian tumors. The use of visible and NIR-I fluorophores has led to beneficial results in clinical trials; however, involving NIR-II dyes s