Fatty Acid Profiles of Leishmania major Derived from Human and Rodent Hosts in Endemic Cutaneous Leishmaniasis Areas of Tunisia and Algeria.
Bouabid C, Yamaryo-Botté Y, Rabhi S, Bichiou H, Hkimi C, Bouglita W, Chaouach M, Eddaikra…
Pathogens 2022
Toxoplasma metabolic flexibility in different growth conditions.
Walsh D, Katris NJ, Sheiner L, Botté CY.
Trends in Parasitology 2022
3D time-lapse imaging of a mouse embryo using intensity diffraction tomography embedded inside a deep learning framework
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Appl Opt 2022
A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in calcium-induced Toxoplasma gondii egress.
Nofal SD, Dominicus C, Broncel M, Katris NJ, Flynn HR, Arrizabalaga G, Botté CY, Invergo…
Plos Pathogens 2022
Alcohol-related hepatocellular carcinoma is a heterogenous condition: Lessons from a latent class analysis
Costentin CE, Minoves M, Kotzki S, Farges O, Goutté N, Decaens T, Bailly S.
Liver Int. 2022 Jul;42(7):1638-1647. doi: 10.1111/liv.15256. Epub 2022 May 11. PMID: 35324065; PMCID: PMC9373918.
Altered splicing of ATG16-L1 mediates acquired resistance to Tyrosine kinase inhibitors of EGFR by blocking autophagy in non-small cell lung cancer
Hatat A.S., Benoit-Pilven C., Pucciarelli A., De Fraipont F., Lamothe L., Perron P., Rey A.,…
Mol Oncol 2022 16 :3490-3508 doi: 10.1002/1878-0261.13229
Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a kinase critical for splicing.
Swale C@, Bellini V, Matthew W. Bowler, Nardella Flore, Marie-Pierre Brenier-Pinchart, Dominique Cannella, Lucid Belmudes,…
Science Translational Medicine 2022 These authors contributed equally: Christopher Swale, Bellini Valeria
Association of Daily Temperature With Suicide Mortality: A Comparison With Other Causes of Death and Characterization of Possible Attenuation Across 5 Decades.
Lehmann F, Alary PE, Rey G, Slama R.
Am J Epidemiol 2022 Aug 22:kwac150
Binding stoichiometry and structural model of the HIV-1 Rev/importin β complex.
Spittler, D., Indorato, RL., Boeri-Erba, E., Delaforge, E., Signor, L., Harris, SJ., Garcia-Saez, I., Palencia,…
Life Science Alliance 2022 5(10):e202201431. doi: 10.26508/lsa.202201431.
Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia
Xi M, Guo S, Bayin C, Peng L, Chuffart F, Bourova-Flin E, Rousseaux S, Khochbin…
Front Med 2022 Jun;16(3):442-458. doi:10.1007/s11684-021-0877-y. Epub 2021 Oct 20. PMID: 34669156.
Chromatin-associated YTHDC1 coordinates heat-induced reprogramming of gene expression
Timcheva K, Dufour S, Touat-Todeschini L, Burnard C, Carpentier MC, Chuffart F, Merret R, Helsmoortel…
Cell Rep. 2022 Dec. # Co-corresponding authors
Chronic Intermittent Hypoxia Increases Cell Proliferation in Hepatocellular Carcinoma
Carreres L, Mercey-Ressejac M, Kurma K, Ghelfi J, Fournier C, Manches O, Chuffart F, Rousseaux…
Cells. 2022 Jun 28;11(13):2051. doi: 10.3390/cells11132051. PMID: 35805134; PMCID: PMC9265377.
Designing local air pollution policies focusing on mobility and heating to avoid a targeted number of pollution-related deaths: Forward and backward approaches combining air pollution modeling, health impact assessment and cost-benefit analysis
Bouscasse H, Gabet S, Kerneis G, Provent A, Rieux C, Ben Salem N, Dupont H,…
Environ Int 2022 Jan 15;159:107030
Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability.
Renaud EA, Pamukcu S, Cerutti A, Berry L, Lemaire-Vieille C, Yamaryo-Botté Y, Botté CY, Besteiro…
Journal of Biological Chemistry 2022
Early delivery following chronic and acute ambient temperature exposure: a comprehensive survival approach
Hough I, Rolland M, Guilbert A, Seyve E, Heude B, Slama R, Lyon-Caen S, Pin…
Int J Epidemiol 2022 Oct 24:dyac190
Ectopic expression of a combination of 5 genes detects high risk forms of T-cell acute lymphoblastic leukemia
Peng LJ, Zhou YB, Geng M, Bourova-Flin E, Chuffart F, Zhang WN, Wang T, Gao…
BMC Genomics 2022 Jun 24;23(1):467. doi:10.1186/s12864-022-08688-1. PMID: 35751016; PMCID: PMC9233359.
Effect of Novel AKT Inhibitor Vevorisertib as Single Agent and in Combination with Sorafenib on Hepatocellular Carcinoma in a Cirrhotic Rat Model
Kurma K, Zeybek Kuyucu A, Roth GS, Sturm N, Mercey-Ressejac M, Abbadessa G, Yu Y,…
Int J Mol Sci. 2022 Dec 19;23(24):16206. doi: 10.3390/ijms232416206. PMID: 36555845; PMCID: PMC9784348.
Exposome Profiles and Asthma Among French Adults
Guillien A, Bédard A, Dumas O, Allegre J, Arnault N, Bochaton A, Druesne-Pecollo N, Dumay…
Am J Respir Crit Care Med. 2022 Jul 11. Online ahead of print.
From azoospermia to macrozoospermia, a phenotypic continuum due to mutations in the ZMYND15 gene.
Kherraf ZE, Cazin C, Bouker A, Fourati Ben Mustapha S, Hennebicq S, Septier A, Coutton…
Am J Hum Genet 2022
GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions
Brun S, Bestion E, Raymond E, Bassissi F, Jilkova ZM, Mezouar S, Rachid M, Novello…
Autophagy. 2022 Mar;18(3):678-694. doi: 10.1080/15548627.2021.1988357. Epub 2021 Nov 5. PMID: 34740311; PMCID: PMC9037544.
Hepatic inflammation elicits production of proinflammatory netrin-1 through exclusive activation of translation.
Barnault R, Verzeroli C, Fournier C, Michelet M, Redavid AR, Chicherova I, Plissonnier ML, Adrait…
Hepatology. 2022 Nov;76(5):1345-1359. doi: 10.1002/hep.32446. Epub 2022 Apr 1. PMID: 35253915.
Homozygous mutations in CCDC34 cause male infertility with oligoasthenoteratozoospermia in humans and mice.
Cong J, Wang X, Amiri-Yekta A, Wang L, Kherraf ZE, Liu C, Cazin C, Tang…
J Med Genet. 2022
HSF1-Activated Non-Coding Stress Response: Satellite lncRNAs and Beyond, an Emerging Story with a Complex Scenario
Vourc'h C, Dufour S, Timcheva K, Seigneurin-Berny D, Verdel A
Genes (Basel) 2022
Human Histone pre-mRNA Assembles Histone- or Canonical-mRNA Processing Complexes by Overlapping 3’-End Sequence Elements
Ielasi, F.S., Ternifi, S., Fontaine, E., Iuso, D., Couté, Y. & *Palencia A.
Nucleic Acids Research 2022 28; 50 (21):12425-12443
Immune responses following tocilizumab therapy to desensitize HLA-sensitized kidney transplant candidates
Jouve T, Laheurte C, Noble J, Weinhard J, Daligault M, Renaudin A, Naciri Bennani H,…
Am J Transplant 2022 Jan;22(1):71-84. doi: 10.1111/ajt.16709. Epub 2021 Jun 23. PMID: 34080291.
In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts
Abellan A, Mensink-Bout SM, Garcia-Esteban R, Beneito A, Chatzi L, Duarte-Salles T, Fernandez MF, Garcia-Aymerich…
Environment International 2022 https://doi.org/10.1016/j.envint.2022.107178
Integrin-based adhesion compartmentalizes ALK3 of the BMPRII to control cell adhesion and migration.
Guevara-Garcia A, Fourel L, Bourrin-Reynard I, Sales A, Oddou C, Pezet M, Rossier O, Machillot…
J Cell Biol. 2022 Dec 5;221(12):e202107110. doi: 10.1083/jcb.202107110. Epub 2022 Oct 7. PMID: 36205720; PMCID: PMC9552562. 2022
Les macrophages associés à la tumeur - De nouvelles cibles pour contrecarrer la chimiorésistance au 5-fluorouracile dans les cancers colorectaux ?
Malier M, Gharzeddine K, Laverriere MH, Decaens T, Roth G, Millet A.
Med Sci (Paris) 2022 Mar;38(3):243-245. doi: 10.1051/medsci/2022017.
Lipoprotein interactions with water-soluble NIR-II emitting aza-BODIPYs boost the fluorescence signal and favor selective tumor targeting
Kalot, G., Godard, A., Busser, B., Bendellaa, M., Dalonneau, F., Paul, C., Le Guével, X.,…
Biomater Sci 2022
Luminescent Peptide/Lanthanide(III) Complex Conjugates with Push-Pull Antennas: Application to One- and Two-Photon Microscopy Imaging.
Choi JH, Fremy G, Charnay T, Fayad N, Pécaut J, Erbek S, Hildebrandt N, Martel-Frachet…
Inorg Chem. 2022 Dec 19;61(50):20674-20689. doi: 10.1021/acs.inorgchem.2c03646. Epub 2022 Dec 7. PMID: 36475655. 2022
Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition
Broséus L, Vaiman D, Tost J, Martin CRS, Jacobi M, Schwartz JD, Béranger R, Slama…
BMC Med 2022 Oct 20;20(1):397
NUT Is a Driver of p300-Mediated Histone Hyperacetylation: From Spermatogenesis to Cancer
Rousseaux S, Reynoird N, Khochbin S.
Cancers (Basel) 2022 Apr 29;14(9):2234. doi: 10.3390/cancers14092234. PMID: 35565363; PMCID:PMC9103113
Oligogenic heterozygous inheritance of sperm abnormalities in mouse
Martinez G, Coutton C, Loeuillet C, Cazin C, Muroňová J, Boguenet M, Lambert E, Dhellemmes…
Elife 2022 Apr 22;11:e75373. doi: 10.7554/eLife.75373.
Optimized outcome prediction of oncogenetic mutations in non-early T-cell precursor acute lymphoblastic leukemia
Peng LJ, Wang SS, Guo SS, Zhang JJ, Liu YF, Rousseaux S, Khochbin S, Chen…
Immunobiology 2022 May;227(3):152205. doi: 10.1016/j.imbio.2022.152205. Epub 2022 Mar 8. PMID:35279479
Phenol and phthalate effects on thyroid hormone levels during pregnancy: Relying on in-vitro assays and Adverse Outcome Pathways to inform an epidemiological analysis
Nakiala D, Noyes P.D, Faure P, Chovelon B, Corne C, Gauchez A.C, Guergour D, Lyon-Caen…
Environ Health Perspect 2022 130(11):117004
PI4-kinase and PfCDPK7 signaling regulate phospholipid biosynthesis in Plasmodium falciparum.
Maurya R, Tripathi A, Kumar M, Antil N, Yamaryo-Botté Y, Kumar P, Bansal P, Doerig…
EMBO Reports 2022 Manipulation, recycling and reassembly of host and existing lipids is vital for parasite lipid homeostasis. This requires both regulating mechanisms and metabolic effectors to do the job. We identified a plant-like Calcium dependent kinase (CDPK7) as bein
R3-AFP score is a new composite tool to refine prediction of hepatocellular carcinoma recurrence after liver transplantation.
Costentin C, Piñero F, Degroote H, Notarpaolo A, Boin IF, Boudjema K, Baccaro C, Podestá…
JHEP Rep. 2022 Feb 2;4(5):100445. doi: 10.1016/j.jhepr.2022.100445. PMID: 35360522; PMCID: PMC8961219.
SMYD3 impedes small cell lung cancer sensitivity to alkylation damage through RNF113A methylation-phosphorylation crosstalk
Lukinović V, Hausmann S, Roth GS, Oyeniran C, Ahmad T, Tsao N, Brickner JR, Casanova…
Cancer Discovery 2022 Sep 2;12(9):2158-2179. doi: 10.1158/2159-8290.CD-21-0205. PMID: 35819319
Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex
Foucher AE, Touat-Todeschini L, Juarez-Martinez AB, Rakitch A, Laroussi H, Karczewski C, Acajjaoui S, Soler-López…
Nat Commun 2022 # Co-corresponding authors
Structural basis of sodium-dependent bile salt uptake into the liver.
Goutam, K., Ielasi, FS., Pardon, E., Steyaert, J., Reyes N.
Nature 2022 606(7916):1015-1020. doi: 10.1038/s41586-022-04723-z
Structural insights into p300 regulation and acetylation-dependent genome organisation
Ibrahim Z, Wang T, Destaing O, Salvi N, Hoghoughi N, Chabert C, Rusu A, Gao…
Nature Communication 2022 Dec 15;13(1):7759. doi: 10.1038/s41467-022-35375-2. PMID: 36522330
Tailoring the SWIR emission of gold nanoclusters by surface ligand rigidification and their application in 3D bioimaging
Le Guevel, X., Wegner, K. D., Wurth, C., Baulin, V. A., Musnier, B., Josserand, V.,…
Chemical communications 2022 58, 2967-2970
The BCC7 Protein Contributes to the Toxoplasma Basal Pole by Interfacing between the MyoC Motor and the IMC Membrane Network
Vigetti L, Labouré T, Roumégous C, Cannella D, Touquet B, Mayer C, Couté Y, Frénal…
Int J Mol Sci 2022 May 26;23(11):5995
The flexibility of Apicomplexa parasites in lipid metabolism.
Shunmugam S, Arnold CS, Dass S, Katris NJ, Botté CY.
The power of parasite collectives
Tolić, I.M., Tardieux, I.
Nat. Phys 2022 May 13; 18:491–492
The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages.
Ten Hoeve AL, Braun L, Rodriguez ME, Olivera GC, Bougdour A, Belmudes L, Couté Y,…
Cell Host Microbe 2022 Oct 20;S1931-3128(22)00512-1.
Therapeutic siRNAs Targeting the JAK/STAT Signalling Pathway in Inflammatory Bowel Diseases
Clément F, Nougarède A, Combe S, Kermarrec F, Dey AK, Obeid P, Millet A, Navarro…
J Crohns Colitis 2022 Feb 23;16(2):286-300. doi: 10.1093/ecco-jcc/jjab129.
Three classes of epigenomic regulators converge to hyperactivate the essential maternal gene deadhead within a heterochromatin mini-domain
Torres-Campana D, Horard B, Denaud S, Benoit G, Loppin B, Orsi GA.
PLoS Genet 2022 Jan 4;18(1):e1009615. doi: 10.1371/journal.pgen.1009615
Trajectories of IgE sensitization to allergen molecules from childhood to adulthood and respiratory health in the EGEA cohort
Siroux V, Boudier A, Bousquet J, Dumas O, Just J, Le Moual N, Nadif R,…
Allergy 2022 Feb;77(2):609-618
Treatment of Mouse Sperm with a Non-Catalytic Mutant of PLA2G10 Reveals That PLA2G10 Improves In Vitro Fertilization through Both Its Enzymatic Activity and as Ligand of PLA2R1.
Abi Nahed R, Dhellemmes M, Payré C, Le Blévec E, Perrier JP, Hennebicq S, Escoffier…
Int J Mol Sci. 2022
Visualizing protein breathing motions associated with aromatic ring flipping
Mariño Perez, L., Ielasi, FS., Bessa, LM., Maurin, D., Kragelj, J., Salvi, N., Bouvignies, G., *Palencia,…
Nature 2022 602, 695-700. *Corresponding authors
When idiopathic male infertility is rooted in maternal malnutrition during the perinatal period in mice.
Muranishi Y, Parry L, Vachette-Dit-Martin M, Saez F, Coudy-Gandilhon C, Sauvanet P, Volle DH, Tournayre…
Biol Reprod 2022
Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia
Am J Hum Genet 2022 Mar 3;109(3):508-517. doi: 10.1016/j.ajhg.2022.01.011. Epub 2022 Feb 15
