Les publications

2-Phenoxy-3-Trichloromethylquinoxalines Are Antiplasmodial Derivatives with Activity against the Apicoplast of Plasmodium falciparum.

Amrane D, Arnold CS, Hutter S, Sanz-Serrano J, Collia M, Azqueta A, Paloque L, Cohen…

Pharmaceuticals (Basel) 2021

An essential vesicular-trafficking phospholipase mediates neutral lipid synthesis and contributes to hemozoin formation in Plasmodium falciparum.

Asad M, Yamaryo-Botté Y, Hossain ME, Thakur V, Jain S, Datta G, Botté CY*, Mohmmed…

BMC Biology 2021

Antiplasmodial 2-thiophenoxy-3-trichloromethyl quinoxalines target the apicoplast of Plasmodium falciparum.

Amrane D, Primas N, Arnold CS, Hutter S, Louis B, Sanz-Serrano J, Azqueta A, Amanzougaghene…

European Journal of Medicinal Chemistry 2021

Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites.

Ashraf K, Tajeri S, Arnold CS, Amanzougaghene N, Franetich JF, Vantaux A, Soulard V, Bordessoulles…

Life Science Alliance 2021

A brain cyst load-associated antigen is a Toxoplasma gondii biomarker for serodetection of persistent parasites and chronic infection

Dard C, Swale C, Brenier-Pinchart MP, Farhat DC, Bellini V, Robert MG, Cannella D, Pelloux…

BMC Biol. 2021 Feb 9;19(1):25

A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.

Lorès P, Kherraf ZE, Amiri-Yekta A, Whitfield M, Daneshipour A, Stouvenel L, Cazin C, Cavarocchi…

Hum Genet. 2021

A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental genes partitioning in Toxoplasma

Farhat DC, Bowler M, Communie G, Pontier D, Belmudes L, Mas C, Coute Y, Bougdour…

Elife 2021 Jul 15;10:e68312

A recurrent ZP1 variant is responsible for oocyte maturation defect with degenerated oocytes in infertile females

Corinne Loeuillet, Magali Dhellemmes, Caroline Cazin, Zine-Eddine Kherraf, Selima Fourati Ben Mustapha, Raoudha Zouari, Nicolas…

Clinical Genetics 2021

A Universal Model for the Log-Normal Distribution of Elasticity in Polymeric Gels and Its Relevance to Mechanical Signature of Biological Tissues

Millet A.

Biology (Basel 2021 Jan 18;10(1):64. doi: 10.3390/biology10010064. 

Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Tsao N, Brickner JR, Rodell R, Ganguly A, Wood M, Oyeniran C, Ahmad T, Sun…

Molecular Cell. 2021 Oct 21;81(20):4228-4242.e8. doi: 10.1016/j.molcel.2021.09.024. PMID: 34686315

Adverse outcome in follicular lymphoma is associated with MYC rearrangements but not MYC extra copies

Bussot L et al.

Br J Haematol 2021

AFU and SALF recommendations for the evaluation of male infertility.

Huyghe E, Boitrelle F, Methorst C, Mieusset R, Ray PF, Akakpo W, Koscinski I, Chalas…

Prog Urol. 2021

Ankrd31 in Sperm and Epididymal Integrity.

Manfrevola F, Martinez G, Coutton C, Rocco D, Reynaud K, Le Vern Y, Froment P,…

Front Cell Dev Biol 2021

Associations between a mixture of phenols and phthalates and child behaviour in a French mother-child cohort with repeated assessment of exposure

Guilbert A, Rolland M, Pin I, Thomsen C, Sakhi AK, Sabaredzovic A, Slama R, Guichardet…

Environ Int 2021 Nov;156:106697

ATAD2 controls chromatin-bound HIRA turnover

Wang T, Perazza D, Boussouar F, Cattaneo M, Bougdour A, Chuffart F, Barral S, Vargas…

Life Sci Alliance 2021 # Co-corresponding authors

Bi-allelic truncating variants in CFAP206 cause male infertility in human and mouse.

Shen Q, Martinez G, Liu H, Beurois J, Wu H, Amiri-Yekta A, Liang D, Kherraf…

Hum Genet 2021

Biallelic variant in cyclin B3 is associated with failure of maternal meiosis II and recurrent digynic triploidy.

Fatemi N, Salehi N, Pignata L, Palumbo P, Cubellis MV, Ramazanali F, Ray P, Varkiani…

J Med Genet 2021

Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch

Miroshnikova YA, Manet S, Li X, Wickström SA, Faurobert E*, Albiges-Rizo C*.

Mol Biol Cell 2021 Aug 19;32(18):1724-1736. doi: 10.1091/mbc.E21-03-0106. Epub 2021 Jun 3. PMID: 34081532; PMCID: PMC8684738.

CCM2-deficient endothelial cells undergo a ROCK-dependent reprogramming into senescence-associated secretory phenotype

Vannier DR, Shapeti A, Chuffart F, Planus E, Manet S, Rivier P, Destaing O, Albiges-Rizo…

Angiogenesis 2021 Nov;24(4):843-860. doi: 10.1007/s10456-021-09809-2. Epub 2021 Aug 3. PMID: 34342749.

Cell fluorescence photoactivation as a method to select and study cellular subpopulations grown in mechanically heterogeneous environments.

Aureille J, Pezet M, Pernet L, Mazzega J, Grichine A, Guilluy C, Dolega ME.

Mol Biol Cell. 2021 Aug 1;32(16):1409-1416. doi: 10.1091/mbc.E20-10-0676. Epub 2021 Jun 16. PMID: 34133212; PMCID: PMC8351743. 2021

CFAP61 is required for sperm flagellum formation and male fertility in human and mouse.

Liu S, Zhang J, Kherraf ZE, Sun S, Zhang X, Cazin C, Coutton C, Zouari…

Development 2021

Chromosome Y pericentric heterochromatin is a primary target of HSF1 in male cells

Penin J, Dufour S, Faure V, Fritah S, Seigneurin-Berny D, Col E, Verdel A#, Vourc'h C#

Chromosoma 2021 # Co-corresponding authors

Combined Use of Whole Exome Sequencing and CRISPR/Cas9 to Study the Etiology of Non-Obstructive Azoospermia: Demonstration of the Dispensable Role of the Testis-Specific Genes C1orf185 and CCT6B.

Cazin C, Neirijnck Y, Loeuillet C, Wehrli L, Kühne F, Lordey I, Mustapha SFB, Bouker…

Cells 2021

Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage

Kerjouan A, Boyault C, Oddou C, Hiriart-Bryant E, Grichine A, Kraut A, Pezet M, Balland…

J Cell Sci. 2021 Jan 25;134(2):jcs254599. doi: 10.1242/jcs.254599. PMID: 33495358.

Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage.

Kerjouan A, Boyault C, Oddou C, Hiriart-Bryant E, Grichine A, Kraut A, Pezet M, Balland…

J Cell Sci. 2021 Jan 25;134(2):jcs254599. doi: 10.1242/jcs.254599. PMID: 33495358. 2021

Correction to: A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.

Lorès P, Kherraf ZE, Amiri-Yekta A, Whitfield M, Daneshipour A, Stouvenel L, Cazin C, Cavarocchi…

Hum Genet. 2021

Cross-talk between the calcium channel TRPV4 and reactive oxygen species interlocks adhesive and degradative functions of invadosomes

Vellino S, Oddou C, Rivier P, Boyault C, Hiriart-Bryant E, Kraut A, Martin R, Coute…

J Cell Biol 2021 Feb 1;220(2):e201910079. doi: 10.1083/jcb.201910079. PMID: 33399853; PMCID: PMC7788461.

Defect in the nuclear pore membrane glycoprotein 210-like gene is associated with extreme uncondensed sperm nuclear chromatin and male infertility: a case report.

Arafah K, Lopez F, Cazin C, Kherraf ZE, Tassistro V, Loundou A, Arnoult C, Thierry-Mieg…

Hum Reprod 2021

Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility.

Liu C, Tu C, Wang L, Wu H, Houston BJ, Mastrorosa FK, Zhang W, Shen…

Am J Hum Genet 2021

DEN-Induced Rat Model Reproduces Key Features of Human Hepatocellular Carcinoma

Kurma K, Manches O, Chuffart F, Sturm N, Gharzeddine K, Zhang J, Mercey-Ressejac M, Rousseaux…

Cancers (Basel) 2021 Oct 4;13(19):4981. doi: 10.3390/cancers13194981

Direction of epithelial folding defines impact of mechanical forces on epithelial state.

Blonski S, Aureille J, Badawi S, Zaremba D, Pernet L, Grichine A, Fraboulet S, Korczyk…

Dev Cell. 2021 Dec 6;56(23):3222-3234.e6. doi: 10.1016/j.devcel.2021.11.008. PMID: 34875225. 2021

Direction of epithelial folding defines impact of mechanical forces on epithelial state.

Blonski S, Aureille J, Badawi S, Zaremba D, Pernet L, Grichine A, Fraboulet S, Korczyk…

Dev Cell. 2021 Dec 6;56(23):3222-3234.e6. doi: 10.1016/j.devcel.2021.11.008. PMID: 34875225. 2021

Enthalpy–entropy compensation in the promiscuous interaction of an intrinsically disordered protein with homologous protein partners.

Kragelj, J., Orand, T., Delaforge, E., Tengo, L., Blackledge, M., Palencia, A. & Jensen, MR.

Biomolecules 2021 11(8):1204. doi: 10.3390/biom11081204.

Extranucleolar CYCLON Staining Pattern Is Strongly Associated to Relapse/Refractory Disease in R-CHOP–treated DLBCL

Bouroumeau A, et al

HemaSphere 2021 Jun 12;5(7):e598

FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells

Jia T, Jacquet T, Dalonneau F, Coudert P, Vaganay E, Exbrayat-Héritier C, Vollaire J, Josserand…

BMC Biology 2021 19(1):173. doi: 10.1186/s12915-021-01103-3

FISH and Chimps: Insights into Frequency and Distribution of Sperm Aneuploidy in Chimpanzees (Pan troglodytes).

Guyot C, Gandula M, Noordermeer W, François-Brazier C, Moigno R, Bessonnat J, Brouillet S, Dhellemmes…

Int J Mol Sci 2021

Genetic analyses of a large cohort of infertile patients with globozoospermia, DPY19L2 still the main actor, GGN confirmed as a guest player.

Celse T, Cazin C, Mietton F, Martinez G, Martinez D, Thierry-Mieg N, Septier A, Guillemain…

Hum Genet. 2021

Genetic diagnosis, sperm phenotype and ICSI outcome in case of severe asthenozoospermia with multiple morphological abnormalities of the flagellum.

Ferreux L, Bourdon M, Chargui A, Schmitt A, Stouvenel L, Lorès P, Ray P, Lousqui…

Hum Reprod 2021

Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer

Malier M, Gharzeddine K, Laverriere MH, Marsili S, Thomas F, Decaens T, Roth G, Millet…

Cancer Res 2021 Dec 1;81(23):5963-5976. doi: 10.1158/0008-5472.CAN-21-1572.

Identification and Characterization of the Most Common Genetic Variant Responsible for Acephalic Spermatozoa Syndrome in Men Originating from North Africa.

Cazin C, Boumerdassi Y, Martinez G, Fourati Ben Mustapha S, Whitfield M, Coutton C, Thierry-Mieg…

Int J Mol Sci 2021

Immortalization of primary sheep embryo kidney cells.

Seridi N, Hamidouche M, Belmessabih N, El Kennani S, Gagnon J, Martinez G, Coutton C,…

In Vitro Cell Dev Biol Anim 2021

Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells.

Dey AK, Gonon A, Pécheur EI, Pezet M, Villiers C, Marche PN.

Cells. 2021 Jan 7;10(1):96. doi: 10.3390/cells10010096. PMID: 33430453; PMCID: PMC7826823. 2021

Investigation of circulating metabolites associated with breast cancer risk by untargeted metabolomics: a case-control study nested within the French E3N cohort

Jobard E, Dossus L, Baglietto L, Fornili M, Lécuyer L, Mancini FR, Gunter MJ, Trédan…

Br J Cancer 2021 May;124(10):1734-1743. doi: 10.1038/s41416-021-01304-1

Ion identity molecular networking for mass spectrometry-based metabolomics in the GNPS environment

Schmid R, Petras D, Nothias LF, Wang M, Aron AT, Jagels A, Tsugawa H, Rainer…

Nature Communications 2021 Jun 22;12(1):3832. doi: 10.1038/s41467-021-23953-9

KH domain containing 3 like (KHDC3L) frame-shift mutation causes both recurrent pregnancy loss and hydatidiform mole.

Fatemi N, Ray PF, Ramezanali F, Shahani T, Amiri-Yekta A, Kherraf ZE, Cazin C, Almadani…

Eur J Obstet Gynecol Reprod Biol 2021

Leucine zipper transcription factor-like 1 (LZTFL1), an intraflagellar transporter protein 27 (IFT27) associated protein, is required for normal sperm function and male fertility.

Huang Q, Li W, Zhou Q, Awasthi P, Cazin C, Yap Y, Mladenovic-Lucas L, Hu…

Dev Biol. 2021

Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution

Gao M, Wang J, Rousseaux S, Tan M, Pan L, Peng L, Wang S, Xu…

Cell Rep 2021 Jul 27;36(4):109460.

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Pfister D, Nunez NG, Pinyol R, Govaere O,…Decaens T, Macek Jilkova Z, et al.

Nature. 2021 Apr;592(7854):450-456. doi: 10.1038/s41586-021-03362-0.

New insights in Cercopithecinae spermatozoa.

Martinez G, Garcia C, Francois-Brazier C, Laidebeure S, Leclerc A, Lecu A, Mulot B, Petit…

Zygote. 2021

Protein kinase TgCDPK7 regulates vesicular trafficking and phospholipid synthesis in Toxoplasma gondii.

Bansal P, Antil N, Kumar M, Yamaryo-Botté Y, Rawat RS, Pinto S, Datta KK, Katris…

Plos Pathogens 2021 Manipulation, recycling and reassembly of host and existing lipids is vital for parasite lipid homeostasis. This requires both regulating mechanisms and metabolic effectors to do the job. We identified a plant-like Calcium dependent kinase (CDPK7) as bein

Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

Chen J, Ellert-Miklaszewska A, Garofalo S, Dey AK, Tang J, Jiang Y, Clément F, Marche…

Nat Protoc. 2021 Jan;16(1):327-351. doi: 10.1038/s41596-020-00418-9. Epub 2020 Dec 4. PMID: 33277630; PMCID: PMC8830918.

The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3 expression predicts aggressive forms of oral squamous cell carcinoma

Bourova-Flin E, Derakhshan S, Goudarzi A, Wang T, Vitte AL, Chuffart F, Khochbin S, Rousseaux…

Br J Cancer 2021 Oct;125(8):1122-1134. doi:10.1038/s41416-021-01491-x. Epub 2021 Jul 21. PMID: 34290392; PMCID: PMC8505643.

The genetic architecture of morphological abnormalities of the sperm tail.

Touré A, Martinez G, Kherraf ZE, Cazin C, Beurois J, Arnoult C, Ray PF, Coutton…

Genet 2021

The sodium/proton exchanger SLC9C1 (sNHE) is essential for human sperm motility and fertility

Cavarocchi E, Whitfield M, Chargui A, Stouvenel L, Lorès P, Coutton C, Arnoult C, Santulli…

Clin Genet 2021 May;99(5):684-693

The sodium/proton exchanger SLC9C1 (sNHE) is essential for human sperm motility and fertility.

Cavarocchi E, Whitfield M, Chargui A, Stouvenel L, Lorès P, Coutton C, Arnoult C, Santulli…

Clin Genet. 2021

The Trypanosome UDP-Glucose Pyrophosphorylase Is Imported by Piggybacking into Glycosomes, Where Unconventional Sugar Nucleotide Synthesis Takes Place.

Villafraz O, Baudouin H, Mazet M, Kulyk H, Dupuy JW, Pineda E, Botté C, Inaoka…

mBio 2021

Toxoplasma LIPIN channels host lipid fluxes sustaining parasite survival through the balance between membrane biogenesis and lipid storage

Dass S*, Shunmugam S*, Berry L, Arnold CS, Duley S., Pierrel F., Katris N, Cesbron…

Nat. Commun 2021 12:2813. doi: 10.1038/s41467-021-22956-w.

Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage.

Dass S, Shunmugam S, Berry L, Arnold CS, Katris NJ, Duley S, Pierrel F, Cesbron-Delauw…

Nature Communications 2021 Apicomplexan parasites require large amount of lipids that can be acquired from both host scavenging and de novo synthesis via the parasites’ own metabolic pathways. Both host and de novo synthesized lipids are essential for parasite membrane biogenesis a

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility

Gadadhar S, Alvarez Viar G, Hansen JN, Gong A, Kostarev A, Ialy-Radio C, Leboucher S,…

Science 2021 Jan 8;371(6525):pii: eabd4914.

Tuning the Immunostimulation Properties of Cationic Lipid Nanocarriers for Nucleic Acid Delivery

Dey AK, Nougarède A, Clément F, Fournier C, Jouvin-Marche E, Escudé M, Jary D, Navarro…

Front Immunol. 2021 Aug 23;12:722411. doi: 10.3389/fimmu.2021.722411. PMID: 34497612; PMCID: PMC8419413.

Untargeted metabolomics approach to discriminate mistletoe commercial products

Vanhaverbeke C, Touboul D, Elie N, Prévost M, Meunier C, Michelland S, Cunin V, Ma…

Sci Rep 2021 11, 14205. doi: 10.1038/s41598-021-93255-z.