Les publications

Aminoacetylation reaction catalyzed by leucyl-tRNA synthetase operates via a self-assisted mechanism using a conserved residue and the aminoacyl substrate.

Aleksandrov, A., Palencia, A., Cusack, S. & Field, M.

Journal of Physical Chemistry B 2016 120(19):4388-98. doi: 10.1021/acs.jpcb.6b02387.

Anti-malarial benzoxaboroles target P. falciparum leucyl-tRNA synthetase.

Sonoiki, E., Palencia, A., Guo, D., Ahyong, V., Dong, C., Li, X., Hernandez, V., Zhang,…

Antimicrobial agents and chemotherapy 2016 60(8):4886-95. doi: 10.1128/AAC.00820-16.

Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

Reynoird N, Mazur PK, Stellfeld T, Flores NM, Lofgren SM, Carlson SM, Brambilla E, Hainaut…

Genes Dev 2016 Apr 1;30(7):772-85. doi: 10.1101/gad.275529.115. Epub 2016 Mar 17. PMID: 26988419

Cryptosporidium and Toxoplasma parasites are inhibited by a benzoxaborole targeting leucyl-tRNA synthetase.

*Palencia, A., Liu, RJ., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, ED., Li,…

Antimicrobial agents and chemotherapy. 2016 60(10):5817-27. doi: 10.1128/AAC.00873-16. *Corresponding Authors.

Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase

Palencia*, A., Li, X., Bu, W., Ding, C., Easom, E., Feng, et al.

Antimicrobial agents and chemotherapy 2016 60(10):6271-80

Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters

Goudarzi A, Zhang D, Huang H, Barral S, Kwon OK, Qi S, Tang Z, Buchou…

Molecular Cell 2016 62:169-180.

Genetic impairment of parasite myosin motors uncovers the contribution of host cell membrane dynamics to Toxoplasma invasion forces

Bichet M, Touquet B, Gonzalez V, Florent I, Meissner M, Tardieux I.

BMC Biol 2016 Nov 9;14(1):97

Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase

Mazur PK, Gozani O, Sage J, Reynoird N.

Transl Cancer Res 2016 Jun;5(3):330-333. doi: 10.21037/tcr.2016.06.26. PMID: 30713830

Nuclear trafficking of EGFR by Vps34 represses Arf expression to promote lung tumor cell survival

Dayde D, Guerard M, Perron P, Hatat A.S, Barrial C, Eymin B and Gazzeri S.

Oncogene 2016 35(30):3986-94. doi: 10.1038/onc.2015.480.

Structural characterisation of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.

Chopra, S.†, Palencia, A.†, et al.

Nature comm 2016 7:12928 †Joint-First Authors