Les publications

A splice donor variant of GAS8 induces structural disorganization of the axoneme in sperm flagella and leads to nonsyndromic male infertility.

Kherraf ZE, Barbotin AL, Martinez G, Mazet A, Cazin C, Coutton C, Arnoult C, Thierry-Mieg…

Clin Genet. 2024

BET inhibition revealed varying MYC dependency mechanisms independent of gene alterations in aggressive B-cell lymphomas

Delrieu L et al.

Clin Epigenetics 2024 Background: MYC-driven lymphomas are a subset of B-cell lymphomas characterized by genetic alterations that dysregulate the expression of the MYC oncogene. When overexpressed, typically through chromosomal translocations, amplifications, or other mechanis

BRCA1 Intragenic Duplication Combined with a Likely Pathogenic TP53 Variant in a Patient with Triple-Negative Breast Cancer: Clinical Risk and Management.

Ea V, Berthozat C, Dreyfus H, Legrand C, Rousselet E, Peysselon M, Baudet L, Martinez…

Int J Mol Sci. 2024

CCDC65, encoding a component of the axonemal Nexin-Dynein regulatory complex, is required for sperm flagellum

Jreijiri F, Cavarocchi E†, Amiri-Yekta A, Cazin C, Hosseini SH, El Khouri E, Patrat C,…

Clin Genet 2024

CCDC65, encoding a component of the axonemal Nexin-Dynein regulatory complex, is required for sperm flagellum

Jreijiri F, Cavarocchi E†, Amiri-Yekta A, Cazin C, Hosseini SH, El Khouri E, Patrat C,…

Clin Genet 2024

CCDC65, encoding a component of the axonemal Nexin-Dynein regulatory complex, is required for sperm flagellum structure in humans.

Jreijiri F, Cavarocchi E, Amiri-Yekta A, Cazin C, Hosseini SH, El Khouri E, Patrat C,…

Clin Genet 2024

CNN-based approach for 3D artifact correction of intensity diffraction tomography images.

Pierré W, Briard M, Godefroy G, Desissaire S, Dhellemmes M, Llano ED, Loeuillet C, Ray…

Opt Express 2024

Complex Endosymbiosis II: The Nonphotosynthetic Plastid of Apicomplexa Parasites (The Apicoplast) and Its Integrated Metabolism.

Quansah N, Charital S, Yamaryo-Botté Y, Botté CY.

Methods in Molecular Biology 2024

Constitutive Androstane Receptor Regulates Germ Cell Homeostasis, Sperm Quality, and Male Fertility via Akt-Foxo1 Pathway.

Monrose M, Holota H, Martinez G, Damon-Soubeyrand C, Thirouard L, Martinot E, Battistelli E, de…

Adv Sci 2024

Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis

A Casanova, G Roth, S Hausmann, X Lu, L Bischoff, E Froeliger, L Belmudes, E…

Cell Discovery 2024

Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis.

Casanova, AG., Roth, GS., Hausmann, S., Lu, X., Bischoff, LJM., Froeliger, EM., ... Rousseaux, S.,…

Cell Discovery 2024 10(1):12. doi: 10.1038/s41421-023-00644-x.

Development of a New Off-the-Shelf Plasmacytoid Dendritic Cell–Based Approach for the Expansion and Characterization of SARS-CoV-2–Specific T Cells

Maino A, Amen A, Plumas J, Bouquet L, Deschamps M, Saas P, Chaperot L, Manches…

J Immunol. 2024 Jan 12:ji2300704. doi: 10.4049/jimmunol.2300704. Epub ahead of print. PMID: 38214610.

Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption

Caroline Nava; Benjamin Cogne; Amandine Santini; Elsa Leitão; François Lecoquierre; Yuyang Chen; Sarah L. Stenton;…

Nature Genetics 2024

ECT2 peptide sequences outside the YTH domain regulate its m6A-RNA binding

Seigneurin-Berny D, Karczewski C, Delaforge E, Yaacoub K, Gaspar Litholdo C Jr, Favory JJ, Ringkjøbing…

RNA Biol. 2024 Jan.

Engineering Radiocatalytic Nanoliposomes with Hydrophobic Gold Nanoclusters for Radiotherapy Enhancement

Carigga Gutierrez, N. M. Clainche, T. L. Bulin, A. L. Leo, S. Kadri, M. Abdelhamid,…

Adv Mater 2024 Chemoradiation therapy is on the forefront of pancreatic cancer care, and there is a continued effort to improve its safety and efficacy. Liposomes are widely used to improve chemotherapy safety, and may accurately deliver high-Z element- radiocatalytic n

Enhanced CRISPR-Cas9 RNA system delivery using cell penetrating peptides-based nanoparticles for efficient in vitro and in vivo applications

Guzman Gonzalez, V. Grunenberger, A. Nicoud, O. Czuba, E. Vollaire, J. Josserand, V. Le Guevel,…

J Control Release 2024 CRISPR-Cas9 system has emerged as a revolutionary gene-editing tool with huge therapeutic potential for addressing the underlying genetic causes of various diseases, including cancer. However, there are challenges such as the delivery method that must be

Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth

Shapeti A, Barrasa-Fano J, Abdel Fattah AR, de Jong J, Sanz-Herrera JA, Pezet M, Assou…

Nat Commun. 2024 Oct 6;15(1):8660. doi: 10.1038/s41467-024-52866-6. PMID: 39370485; PMCID: PMC11456588.

Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth

Shapeti A, Barrasa-Fano J, Abdel Fattah AR, de Jong J, Sanz-Herrera JA, Pezet M, Assou…

Nat Commun. 2024 Oct 6;15(1):8660. doi: 10.1038/s41467-024-52866-6. PMID: 39370485; PMCID: PMC11456588.

In vitro production of cat-restricted Toxoplasma pre-sexual stages

Ana Vera Antunes, Martina Shahinas, Christopher Swale, Dayana C. Farhat, Chandra Ramakrishnan, Christophe Bruley, Dominique…

Nature 2024 These authors contributed equally: Ana Vera Antunes, Martina Shahinas, Christopher Swale

Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse

Muroňová J, Kherraf ZE, Giordani E, Lambert E, Eckert S, Cazin C, Amiri-Yekta A, Court…

Elife 2024

Liver cancer in ovo models for preclinical testing

Garcia P, Wang Y, Viallet J, Mehdi NEH, Montaut E, Decaens T, Emadali A, Macek…

FASEB J 2024 Sep 15;38(17):e70029. doi: 10.1096/fj.202401416R. PMID: 39215630.

Long-term intermittent hypoxia in mice induces inflammatory pathways implicated in sleep apnea and steatohepatitis in humans.

Gaucher J, Montellier E, Vial G, Chuffart F, Guellerin M, Bouyon S, Lemarie E, Yamaryo-Botté…

iScience 2024

Metabolic reprogramming of hypoxic tumor-associated macrophages through CSF-1R targeting favors treatment efficiency in colorectal cancers.

Gharzeddine K, Gonzalez Prieto C, Malier M, Hennot C, Grespan R, Yamaryo-Botté Y, Botté CY,…

Journal for Immunotherapy of Cancer 2024

Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers

Khaldoun Gharzeddine, Cristina Gonzales Pietro, Marie Malier, Clara Hennot, Renata Grespan, Yoshiki Yamaryo-Botté, Cyrille Y.…

BioRxiv 2024

Methylation of ESCRT-III components regulates the timing of cytokinetic abscission

Richard A, Berthelet J, Judith D, Advedissian T, Espadas J, Jannot G, Amo A, Loew…

Nat Commun. 2024

Monitoring of Lipid Fluxes Between Host and Plastid-Bearing Apicomplexan Parasites.

Charital S, Lourdel A, Quansah N, Botté CY, Yamaryo-Botté Y.

Methods in Molecular Biology 2024

Nanoscintillator Coating: A Key Parameter That Strongly Impacts Internalization, Biocompatibility, and Therapeutic Efficacy in Pancreatic Cancer Models

Aubrun Fulbert, Clémentine Chaput, Frédéric Stelse‐Masson, Sarah Henry, Maxime Chovelon, Benoit Bohic, Sylvain Brueckner, Dennis…

Small Science 2024 Pancreatic cancer is associated with a poor prognosis despite multimodal treatments. To improve the efficacy of radiotherapy, the use of nanoscintillators is emerging. Made of high-Z elements, they absorb X-rays more efficiently than tissues and can local

Optogenetically controlled inflammasome activation demonstrates two phases of cell swelling during pyroptosis

Nadjar J, Monnier S, Bastien E, Huber AL, Oddou C, Bardoulet L, Leloup HB, Ichim…

Sci Signal. 2024 Apr 23;17(833):eabn8003. doi: 10.1126/scisignal.abn8003. Epub 2024 Apr 23. PMID: 38652763.

PD1 and TIM3 Expression is Associated with Very Early Hepatocellular Carcinoma Recurrence After Percutaneous Thermal Ablation

Ghelfi J, Macek Jilkova Z , Sengel C, Brusset B, Teyssier Y, Costentin C, Mercey-Ressejac…

Journal of Hepatocellular Carcinoma. 2024 https://doi.org/10.2147/JHC.S443134

Phage display identification of high-affinity ligands for human TSG101-UEV: A structural and thermodynamic study of PTAP recognition.

Murciano-Calles, J., Rodríguez-Martínez, A., Palencia, A., Andújar-Sánchez, M., Iglesias-Bexiga, M., Corbi-Verge, C., Buzón, P., Ruiz-Sanz,…

Int J Biol Macromol. 2024 274(1):133233, 10.1016.

Quantifying Titanium Exposure in Lung Tissues: A Novel Laser‐Induced Breakdown Spectroscopy Elemental Imaging‐Based Analytical Framework for Biomedical Application

Gardette, V. Sancey, L. Leprince, M. Gaté, L. Cosnier, F. Seidel, C. Valentino, S. Pelascini,…

Small Science 2024 Occupational and environmental exposures, particularly those related to urban and suburban atmospheres, are increasingly linked to a range of pulmonary diseases. While diagnostic methods for these diseases are well established, analytical tools for assess

Roles of zinc in cancers: From altered metabolism to therapeutic applications

Bendellaa, M. Lelievre, P. Coll, J. L. Sancey, L. Deniaud, A. Busser, B.

Int J Cancer 2024 Zinc (Zn) is a crucial trace element involved in various cellular processes, including oxidative stress, apoptosis and immune response, contributing to cellular homeostasis. Dysregulation of Zn homeostasis occurs in certain cancers. This review discusses

Serum IGF1 Is a Prognostic Marker for Resistance to Targeted Therapies and a Predictive Marker for Anti-IGF1 Receptor Therapy in Melanoma

Castillo-Ferrer, C. Marguet, T. Vanwonterghem, L. Erbek, S. Chuffart, F. Mouret, S. Messai, S. T.…

J Invest Dermatol 2024 Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenoble Alpes University, Grenoble, France; Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France. Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenobl

Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1

Mariño Pérez, L., Ielasi, FS., Lee, A., Delaforge, E., Juyoux, P., Tengo, M., Davis, RJ.,…

Structure 2024 S0969-2126(24)00228-4. doi: 10.1016/j.str.2024.06.010

Submicrometre spatiotemporal characterization of the Toxoplasma adhesion strategy for gliding motility

Vigetti L, Touquet B, Debarre D, Rose T, Bureau L, Abdallah D, Dubacheva GV, Tardieux…

Nat Microbiol. 2024 Dec;9(12):3148-3164

Targeting a microbiota Wolbachian aminoacyl-tRNA synthetase to block its pathogenic host.

Hoffmann, G., Lukarska, M., Clare, RH., Masters, EKG., Johnston, KL., Ford, L., Turner, JD., Ward,…

Science Advances 2024 10(28):eado1453. doi: 10.1126/sciadv.ado1453.

The acyl-CoA synthetase Tg ACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions

Charital S

mBio 2024 Apicomplexa parasites cause major diseases such as toxoplasmosis and malaria that have major health and economic burdens. These unicellular pathogens are obligate intracellular parasites that heavily depend on lipid metabolism for the survival within thei

The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions.

Charital S, Shunmugam S, Dass S, Alazzi AM, Arnold C-S, Katris NJ, Duley S, Quansah…

mBio 2024 Lipid and fatty acid acquisition is crucial for apicomplexa survival. In this work, we identified 7 enzymes required for parasite fatty acid activation, acyl-CoA synthetases (ACS). We show that TgACS1 is crucial to allow parasite motility, and hence host

The annulus: composition, role and importance in sperm flagellum biogenesis and male fertility.

Whitfield M.

Basic Clin Androl. 2024

The antimicrobial activity of ETD151 defensin is dictated by the presence of glycosphingolipids in the targeted organisms.

Kharrat O, Yamaryo-Botté Y, Nasreddine R, Voisin S, Aumer T, Cammue BPA, Madinier JB, Knobloch…

PNAS 2024

Toxoplasma acyl-CoA synthetase TgACS3 is crucial to channel host fatty acids in lipid droplets and for parasite propagation.

Dass S, Shunmugam S, Charital S, Duley S, Arnold CS, Katris NJ, Cavaillès P, Cesbron-Delauw…

Journal of Lipid Research 2024

WazaGaY: An Innovative Aza-BODIPY-Derived Near-Infrared Fluorescent Probe for Enhanced Tumor Imaging

Bendellaa M, Cave C, Godard A, Dalonneau F, Sickinger A, Goze C, Maury O, Le…

J Med Chem 2024 Sep 26;67(18):16635-16648. doi: 10.1021/acs.jmedchem.4c01435. Epub 2024 Sep 17. PMID: 39289797.