Les publications

A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma.

Arnold CS, Alazzi AM, Shunmugam S, Janouškovec J, Berry L, Charital S, Gautier T, Duley…

Nature Communications 2025 Lipids are crucial for Apicomplexa survival in their human hosts. They can acquire lipids from the host cell and/or make its own in a relict non-photosynthetic and essential plastid, the apicoplast, which represents a plant-like Achilles’ Heel for the par

ATAD2 mediates chromatin-bound histone chaperone turnover

Ariadni Liakopoulou; Fayçal Boussouar; Daniel Perazza; Sophie Barral; Emeline Lambert; Tao Wang; Florent Chuffart; Ekaterina…

eLife 2025

3-Benzylmenadiones and their Heteroaromatic Analogues Target the Apicoplast of Apicomplexa Parasites: Synthesis and Bioimaging Studies.

Dupouy B, Donzel M, Roignant M, Charital S, Keumoe R, Yamaryo-Botté Y, Feckler A, Bundschuh…

ACS Infectious Diseases 2025

A comprehensive study of the sperm head defects in MMAF condition and their impact on embryo development in mice

Jana Muroňová, Emeline Lambert, Chanyuth Thamwan, Zeina Wehbe, Magali Court, Geneviève Chevalier, Jessica Escoffier, Zine-Eddine…

Molecular Humain Reproduction 2025

A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions.

Bitew MA, Paredes-Santos TC, Maru P, Krishnamurthy S, Wang Y, Sangaré LO, Duley S, Yamaryo-Botté…

Nature Communications (accepted) 2025

A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei.

Zeeshan M, Blatov I, Yanase R, Ferguson DJP, Pashley SL, Chahine Z, Yamaryo-Botté Y, Mishra…

Elife 2025

A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma

Arnold CS et aL.

Nat Commun 2025 Toxoplasma gondii, an apicomplexan parasite and agent of the human disease toxoplasmosis, possesses a non-photosynthetic relic plastid, named the apicoplast. Thought to be evolved from a red algal plastid, the apicoplast houses major metabolic pathways, s

A recurrent loss-of-function variant in DRC1 causes non-syndromic severe asthenozoospermia with favorable intracytoplasmic sperm injection and pregnancy outcomes

Célia Tebbakh, Anne-Laure Barbotin, Guillaume Martinez, Angèle Boursier, Zeina Wehbe, Asma Hammouda, Nicolas Thierry-Mieg, Christophe…

Andrology 2025

Bipartite binding of the intrinsically disordered scaffold protein JIP1 to the kinase JNK1.

Orand, T., Delaforge, E., Lee, A., Kragelj, J., Davis, RJ., Palencia, A.*, Jensen, MR.*

Proceedings of the National Academy of Sciences of USA. 2025

Combined physical and biological contributions to radiotherapy enhancement by Lu-based nanoscintillators in pancreatic cancer models.

Stelse-Masson, S., Lytvynenko, X., Bedregal-Portugal, K., Aubrun, C., Lavaud, M., Kadri, M., Jacquet, T., Moriscot,…

Nanotheranostics 2025 Methods: In this paper, we study the ability of Lu 3 Al 5 O 12: Pr@ SiO 2, a lutetium-based nanoscintillator, to exert a radiation dose-enhancement effect in two human pancreatic cancer cell models, namely PANC-1 and MIA PaCa-2. Results: Lu 3 Al 5 O 12:

Deciphering the Contribution of Circular RNAs to Age-Related Decline in Sertoli Cell Survivor.

Manfrevola F, Mosca N, Mele VG, Chioccarelli T, Martinez G, Coutton C, Mattia M, Pezzullo…

Aging Cell 2025

Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption.

Nava C, … Charbonnier C, Charenton C, Thevenon J, Depienne C

Nat Genet. 2025 Jun;57(6):1374-1388. doi: 10.1038/s41588-025-02184-4. Epub 2025 May 16. PMID: 40379786; PMCID: PMC12165858.

HBV and HBsAg strongly reshape the phenotype, function, and metabolism of DCs according to patients' clinical stage

Dumolard L, Gerster T, Chuffart F, Decaens T, Hilleret MN, Larrat S, Saas P, Jouvin-Marche…

Hepatol Commun. 2025 Jan 29;9(2):e0625. doi: 10.1097/HC9.0000000000000625. PMID: 39878655; PMCID: PMC11781764.

Homozygous deleterious variants in MYCBPAP induce asthenoteratozoospermia involving abnormal acrosome biogenesis, manchette structure and sperm tail assembly in humans and mice

Yiling Zhou, Chaofeng Tu, Charles Coutton, Jianan Tang, Shixiong Tian, Shuyan Tang, Guillaume Martinez, Dapeng…

Science China Life Science 2025

Human Asthenozoospermia due to sperm morphological and functional defects: Update on Genetic Causes, Patient Management and Clinical Strategies

Cavarocchi E, Drouault M, Ribeiro JC, Simon V, Whitfield M† and Touré A

Andrology 2025

Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential

Wei K. et al.

Advanced Science 2025 The fungal Bromodomain and Extra-Terminal (BET) protein Bdf1 is a potential antifungal target against invasive fungal infections. However, the need to selectively inhibit both Bdf1 bromodomains (BDs) over human orthologs and the lack of molecular tools to

Hydrogenous and deuterated phospholipid extracts from Escherichia coli as biomimetic cytoplasmic bacterial membranes.

Corucci G, Sánchez-Puga P, Batchu KC, Paracini N, Micciulla S, Laux V, Carrascosa-Tejedor J, Frewein…

Chemistry and Physics of Lipids 2025

Hypothermic Oxygenated Machine Perfusion and Static Cold Storage Drive Distinct Immunomodulation During Liver Transplantation: A Pilot Study

Aspord C, Macek Jílková Z, Bonadona A, Gerster T, Lesurtel M, Girard E, Saas P,…

Transplantation. 2025 Apr 1;109(4):658-670. doi: 10.1097/TP.0000000000005274. Epub 2024 Dec 11. PMID: 40131763.

Identification of immunogenic HLA-A*02:01 epitopes associated with HCC for immunotherapy development

Maino A, Bourov A-Flin E, Decaens T, Khochbin S, Macek Jilkova Z, Rousseaux S, Plumas…

Hepatol Commun. 2025 2025 Feb 26;9(3):e0659. doi: 10.1097/HC9.0000000000000659. PMID: 40008881; PMCID: PMC11868434

In vivo vectorization and delivery systems for gene therapies and RNA-based therapeutics in oncology

Schock Vaiani, J. Broekgaarden, M. Coll, J. L. Sancey, L. Busser, B.

Nanoscale 2025 Gene and RNA-based therapeutics represent a promising frontier in oncology, enabling targeted modulation of tumor-associated genes and proteins. This review explores the latest advances in payload vectorization and delivery systems developed for in vivo c

MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma

Niveau C, Cettour-Cave M, Mouret S, Sosa Cuevas E, Pezet M, Roubinet B, Gil H,…

Nat Commun. 2025 Jan 27;16(1):1083. doi: 10.1038/s41467-025-56392-x. PMID: 39870647; PMCID: PMC11772620.

Monomer Versus Dimer of Cationic Ir(III) Complexes for Photodynamic Therapy by Two-Photon Activation: A Comparative Study.

Barta, A., Vanwonterghem, L., Lavaud, M., Molton, F., Micouin, G., Bulin, A. L., Banyasz, A.,…

ACS Appl Bio Mater 2025 Iridium(III) complexes have been recognized as promising candidates for two-photon sensitized photodynamic therapy (PDT). In this context, we report on the study of two complexes: a monomer (IrL(1)) and a dimer (Ir(2)L(2)). Both complexes possess 2-phenyl

Multifunctional micro/nano-textured titanium with bactericidal, osteogenic, angiogenic and anti-inflammatory properties: Insights from in vitro and in vivo studies

Ziegelmeyer, T. Martins de Sousa, K. Liao, T. Y. Lartizien, R. Delay, A. Vollaire, J.…

Mater Today Bio 2025 Titanium (Ti) is widely used as an implantable material for bone repair in orthopedics and dentistry. However, Ti implants are vulnerable to bacterial infections, which can compromise patient recovery and lead to implant failure. While a controlled inflam

Nanostructured lipid carriers based mRNA vaccine leads to a T cell-inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a cold tumour model

Fournier C, Mercey-Ressejac M, Derangère V, Al Kadi A, Rageot D, Charrat C, Leroy A,…

EBioMedicine. 2025 Feb;112:105543. doi: 10.1016/j.ebiom.2024.105543. Epub 2025 Jan 9. PMID: 39793480; PMCID: PMC11774803.

Personal exposure to air pollutants and immune system biomarkers in pregnant women

Marsal A, Frau L, Chaperot L, Amine I, Lyon-Caen S, Boudier A, Jaffrezo JL, Elazzouzi…

Sci Rep. 2025 May 21;15(1):17672. doi: 10.1038/s41598-025-98712-7. PMID: 40399383; PMCID: PMC12095663.

Phenotypic continuum and poor intracytoplasmic sperm injection intracytoplasmic sperm injection prognosis in patients harboring HENMT1 variants

Zeina Wehbe, Anne-Laure Barbotin, Angèle Boursier, Caroline Cazin, Jean-Pascal Hograindleur, Marie Bidart, Emeline Fontaine, Pauline…

Andrology 2025

Self-Assembled Peptide-Gold Nanoclusters with SiRNA Targeting Telomeric Response to Enhance Radiosensitivity in Lung Cancer Cells

Moro, S., Omrani, M., Erbek, S., Jourdan, M., Vandekerckhove, C. I., Nogier, C., Vanwonterghem, L.,…

Small Science 2025 Lung cancer cells resistant to radiotherapy present a significant clinical challenge. Stable telomeric structures, maintained by the TRF2 protein, play a critical role in protecting cells from ionizing radiation. Reduced TRF2 expression increases DNA dama

Sperm fertility in mice with Oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA.

Vilpreux C, Martinez G, Court M, Appaix F, Duteyrat JL, Henry M, Vollaire J, Ayad…

eLife 2025

SRSF2 overexpression induces transcription-/replication-dependent DNA double-strand breaks and interferes with DNA repair pathways to promote lung tumor progression

Khalife M, Jia T, Caron P, Shreim A, Genoux A, Cristini A, Pucciarelli A, Leverve…

NAR Cancer. 2025 Apr 2;7(2):zcaf011. doi: 10.1093/narcan/zcaf011. PMID: 40181846; PMCID: PMC11963763.

The physicochemical and biochemical mechanisms of porphyrinoid-mediated radiodynamic therapy.

Leo, S., Carigga Gutierrez, N. M., Bulin, A. L., Coll, J. L., Sancey, L., Habermeyer,…

Eur J Med Chem 2025 Radiotherapy is the standard treatment for nearly 60 % of cancer patients. Despite advancements such as brachytherapy, stereotactic radiotherapy, and intensity-modulated radiotherapy, further improvements in efficacy and safety are needed. Radiodynamic th

Transcription-replication conflict resolution by nuclear RNA interference

Teri Cheng; Benjamin Roche; Farida Abderahmane; Leila Touat-Todeschini; Karine Fréon; Asad A. Lakhani; Sonali Bhattacharjee;…

Molecular Cell 2025

Whole genome sequencing identifies a homozygous splicing variant in TDRKH segregating with non-obstructive azoospermia in an Iranian family

Amir Amiri-Yekta, Sharanya Sen, Florence Hazane-Puch, Célia Tebbakh, Nathalie Roux-Buisson, Caroline Cazin, Nicolas Thierry-Mieg, Ahmed…

Clinical Genetics 2025