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Institute for
Advanced Biosciences

The IAB is an internationally renowned institute in fundamental and translational biomedical research based in Grenoble.

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Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis

A Casanova, G Roth, S Hausmann, X Lu, L Bischoff, E Froeliger, L Belmudes, E…

Cell Discovery 2024 Malignant forms of breast cancer refractory to existing therapies remain a major unmet health issue, primarily due to metastatic spread. A better understanding of the mechanisms at play will provide better insights for alternative treatments to prevent br

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Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis.

Casanova, AG., Roth, GS., Hausmann, S., Lu, X., Bischoff, LJM., Froeliger, EM., ... Rousseaux, S.,…

Cell Discovery 2024 10(1):12. doi: 10.1038/s41421-023-00644-x.

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Development of a New Off-the-Shelf Plasmacytoid Dendritic Cell–Based Approach for the Expansion and Characterization of SARS-CoV-2–Specific T Cells

Maino A, Amen A, Plumas J, Bouquet L, Deschamps M, Saas P, Chaperot L, Manches…

J Immunol. 2024 Jan 12:ji2300704. doi: 10.4049/jimmunol.2300704. Epub ahead of print. PMID: 38214610.

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In vitro production of cat-restricted Toxoplasma pre-sexual stages

Ana Vera Antunes, Martina Shahinas, Christopher Swale, Dayana C. Farhat, Chandra Ramakrishnan, Christophe Bruley, Dominique…

Nature 2024 These authors contributed equally: Ana Vera Antunes, Martina Shahinas, Christopher Swale

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Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers

Khaldoun Gharzeddine, Cristina Gonzales Pietro, Marie Malier, Clara Hennot, Renata Grespan, Yoshiki Yamaryo-Botté, Cyrille Y.…

BioRxiv 2024

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PD1 and TIM3 Expression is Associated with Very Early Hepatocellular Carcinoma Recurrence After Percutaneous Thermal Ablation

Ghelfi J, Macek Jilkova Z , Sengel C, Brusset B, Teyssier Y, Costentin C, Mercey-Ressejac…

Journal of Hepatocellular Carcinoma. 2024 https://doi.org/10.2147/JHC.S443134

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Phage display identification of high-affinity ligands for human TSG101-UEV: A structural and thermodynamic study of PTAP recognition.

Murciano-Calles, J., Rodríguez-Martínez, A., Palencia, A., Andújar-Sánchez, M., Iglesias-Bexiga, M., Corbi-Verge, C., Buzón, P., Ruiz-Sanz,…

Int J Biol Macromol. 2024 274(1):133233, 10.1016.

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Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1

Mariño Pérez, L., Ielasi, FS., Lee, A., Delaforge, E., Juyoux, P., Tengo, M., Davis, RJ.,…

Structure 2024 S0969-2126(24)00228-4. doi: 10.1016/j.str.2024.06.010

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Targeting a microbiota Wolbachian aminoacyl-tRNA synthetase to block its pathogenic host.

Hoffmann, G., Lukarska, M., Clare, RH., Masters, EKG., Johnston, KL., Ford, L., Turner, JD., Ward,…

Science Advances 2024 10(28):eado1453. doi: 10.1126/sciadv.ado1453.

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Aberrant activation of five embryonic stem cell-specific genes robustly predicts a high risk of relapse in breast cancers

Jacquet E, Chuffart F, Vitte AL, Nika E, Mousseau M, Khochbin S, Rousseaux S, Bourova-Flin…

BMC Genomics 2023 Aug 17;24(1):463. doi: 10.1186/s12864-023-09571-3. PMID: 37592220; PMCID:PMC10436393

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IAB counts 19 teams
and near 300 people

Apicolipide

Photo Cyrille BOTTÉ

Cyrille BOTTÉ

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Biomechanics of Host-Parasite Interactions

Photo Isabelle TARDIEUX

Isabelle TARDIEUX

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Cancer Targets and Experimental Therapeutics

Photo Jean-Luc COLL

Jean-Luc COLL

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Cell adhesion dynamics and Differentiation

Photo Corinne ALBIGÈS-RIZO

Corinne ALBIGÈS-RIZO

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Cell Dynamics, Immunity, Metabolism & Cancer

Photo Pierre HAINAUT

Pierre HAINAUT

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Dynamique du Cytosquelette et fonctions Nucléaires

Photo Laurence LAFANECHÈRE

Laurence LAFANECHÈRE

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Environmental Epidemiology applied to Development and Respiratory Health (EDES)

Photo Valérie SIROUX

Valérie SIROUX

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Epigenetic Regulations

Photo Saadi KHOCHBIN

Saadi KHOCHBIN

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Epigenetics of Regeneration and Cancer (E-ReCa)

Photo Guillermo ORSI

Guillermo ORSI

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Genetics, Epigenetics and therapies of infertility

Photo Christophe ARNOULT

Christophe ARNOULT

Photo Pierre RAY

Pierre RAY

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Génomique Translationnelle

Photo Julien THEVENON

Julien THEVENON

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Mechanobiology, Immunity and Cancer

Photo Arnaud MILLET

Arnaud MILLET

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Physiology and Pathophysiology of Sperm cells

Photo Aminata TOURÉ

Aminata TOURÉ

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Protein methylation dynamics in cancer

Photo Nicolas REYNOIRD

Nicolas REYNOIRD

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RNA splicing, Cell signaling and Response to Therapies

Photo Béatrice EYMIN

Béatrice EYMIN

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RNA, Epigenetics & Stress

Photo André VERDEL

André VERDEL

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Structural Biology of Novel Targets in Human Diseases

Photo Andrés PALENCIA

Andrés PALENCIA

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Toxoplasmosis & Host-parasite coevolution

Photo Mohamed-Ali HAKIMI

Mohamed-Ali HAKIMI

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Translational Epigenetics

Photo Jérôme GOVIN

Jérôme GOVIN

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See Teams

Some Numbers

19

Teams

300

people

27

nationalities

118

researchers and teachers

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