Institute for
Advanced Biosciences

Bipartite binding of the intrinsically disordered scaffold protein JIP1 to the kinase JNK1.

Orand, T., Delaforge, E., Lee, A., Kragelj, J., Davis, RJ., Palencia, A.*, Jensen, MR.*

Proceedings of the National Academy of Sciences of USA. 2025

In vivo vectorization and delivery systems for gene therapies and RNA-based therapeutics in oncology

Schock Vaiani, J. Broekgaarden, M. Coll, J. L. Sancey, L. Busser, B.

Nanoscale 2025 Gene and RNA-based therapeutics represent a promising frontier in oncology, enabling targeted modulation of tumor-associated genes and proteins. This review explores the latest advances in payload vectorization and delivery systems developed for in vivo c

Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis

A Casanova, G Roth, S Hausmann, X Lu, L Bischoff, E Froeliger, L Belmudes, E…

Cell Discovery 2024

Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis.

Casanova, AG., Roth, GS., Hausmann, S., Lu, X., Bischoff, LJM., Froeliger, EM., ... Rousseaux, S.,…

Cell Discovery 2024 10(1):12. doi: 10.1038/s41421-023-00644-x.

Development of a New Off-the-Shelf Plasmacytoid Dendritic Cell–Based Approach for the Expansion and Characterization of SARS-CoV-2–Specific T Cells

Maino A, Amen A, Plumas J, Bouquet L, Deschamps M, Saas P, Chaperot L, Manches…

J Immunol. 2024 Jan 12:ji2300704. doi: 10.4049/jimmunol.2300704. Epub ahead of print. PMID: 38214610.

Engineering Radiocatalytic Nanoliposomes with Hydrophobic Gold Nanoclusters for Radiotherapy Enhancement

Carigga Gutierrez, N. M. Clainche, T. L. Bulin, A. L. Leo, S. Kadri, M. Abdelhamid,…

Adv Mater 2024 Chemoradiation therapy is on the forefront of pancreatic cancer care, and there is a continued effort to improve its safety and efficacy. Liposomes are widely used to improve chemotherapy safety, and may accurately deliver high-Z element- radiocatalytic n

Enhanced CRISPR-Cas9 RNA system delivery using cell penetrating peptides-based nanoparticles for efficient in vitro and in vivo applications

Guzman Gonzalez, V. Grunenberger, A. Nicoud, O. Czuba, E. Vollaire, J. Josserand, V. Le Guevel,…

J Control Release 2024 CRISPR-Cas9 system has emerged as a revolutionary gene-editing tool with huge therapeutic potential for addressing the underlying genetic causes of various diseases, including cancer. However, there are challenges such as the delivery method that must be

In vitro production of cat-restricted Toxoplasma pre-sexual stages

Ana Vera Antunes, Martina Shahinas, Christopher Swale, Dayana C. Farhat, Chandra Ramakrishnan, Christophe Bruley, Dominique…

Nature 2024 These authors contributed equally: Ana Vera Antunes, Martina Shahinas, Christopher Swale

Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers

Khaldoun Gharzeddine, Cristina Gonzales Pietro, Marie Malier, Clara Hennot, Renata Grespan, Yoshiki Yamaryo-Botté, Cyrille Y.…

BioRxiv 2024

Methylation of ESCRT-III components regulates the timing of cytokinetic abscission

Richard A, Berthelet J, Judith D, Advedissian T, Espadas J, Jannot G, Amo A, Loew…

Nat Commun. 2024