Institut pour
l’Avancée des Biosciences

A recurrent loss-of-function variant in DRC1 causes non-syndromic severe asthenozoospermia with favorable intracytoplasmic sperm injection and pregnancy outcomes

Tebbakh C, Barbotin AL, Martinez G, Boursier A, Wehbe Z, Hammouda A, Thierry-Mieg N, Arnoult…

Andrology 2025

A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma

Arnold CS et aL.

Nat Commun 2025 Toxoplasma gondii, an apicomplexan parasite and agent of the human disease toxoplasmosis, possesses a non-photosynthetic relic plastid, named the apicoplast. Thought to be evolved from a red algal plastid, the apicoplast houses major metabolic pathways, s

Bipartite binding of the intrinsically disordered scaffold protein JIP1 to the kinase JNK1.

Orand, T., Delaforge, E., Lee, A., Kragelj, J., Davis, RJ., Palencia, A.*, Jensen, MR.*

Proceedings of the National Academy of Sciences of USA. 2025

Combined physical and biological contributions to radiotherapy enhancement by Lu-based nanoscintillators in pancreatic cancer models.

Stelse-Masson, S., Lytvynenko, X., Bedregal-Portugal, K., Aubrun, C., Lavaud, M., Kadri, M., Jacquet, T., Moriscot,…

Nanotheranostics 2025 Methods: In this paper, we study the ability of Lu 3 Al 5 O 12: Pr@ SiO 2, a lutetium-based nanoscintillator, to exert a radiation dose-enhancement effect in two human pancreatic cancer cell models, namely PANC-1 and MIA PaCa-2. Results: Lu 3 Al 5 O 12:

Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential

Wei K. et al.

Advanced Science 2025 The fungal Bromodomain and Extra-Terminal (BET) protein Bdf1 is a potential antifungal target against invasive fungal infections. However, the need to selectively inhibit both Bdf1 bromodomains (BDs) over human orthologs and the lack of molecular tools to

In vivo vectorization and delivery systems for gene therapies and RNA-based therapeutics in oncology

Schock Vaiani, J. Broekgaarden, M. Coll, J. L. Sancey, L. Busser, B.

Nanoscale 2025 Gene and RNA-based therapeutics represent a promising frontier in oncology, enabling targeted modulation of tumor-associated genes and proteins. This review explores the latest advances in payload vectorization and delivery systems developed for in vivo c

Monomer Versus Dimer of Cationic Ir(III) Complexes for Photodynamic Therapy by Two-Photon Activation: A Comparative Study.

Barta, A., Vanwonterghem, L., Lavaud, M., Molton, F., Micouin, G., Bulin, A. L., Banyasz, A.,…

ACS Appl Bio Mater 2025 Iridium(III) complexes have been recognized as promising candidates for two-photon sensitized photodynamic therapy (PDT). In this context, we report on the study of two complexes: a monomer (IrL(1)) and a dimer (Ir(2)L(2)). Both complexes possess 2-phenyl

Multifunctional micro/nano-textured titanium with bactericidal, osteogenic, angiogenic and anti-inflammatory properties: Insights from in vitro and in vivo studies

Ziegelmeyer, T. Martins de Sousa, K. Liao, T. Y. Lartizien, R. Delay, A. Vollaire, J.…

Mater Today Bio 2025 Titanium (Ti) is widely used as an implantable material for bone repair in orthopedics and dentistry. However, Ti implants are vulnerable to bacterial infections, which can compromise patient recovery and lead to implant failure. While a controlled inflam

Self-Assembled Peptide-Gold Nanoclusters with SiRNA Targeting Telomeric Response to Enhance Radiosensitivity in Lung Cancer Cells

Moro, S., Omrani, M., Erbek, S., Jourdan, M., Vandekerckhove, C. I., Nogier, C., Vanwonterghem, L.,…

Small Science 2025 Lung cancer cells resistant to radiotherapy present a significant clinical challenge. Stable telomeric structures, maintained by the TRF2 protein, play a critical role in protecting cells from ionizing radiation. Reduced TRF2 expression increases DNA dama

Sperm fertility in mice with Oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA.

Vilpreux C, Martinez G, Court M, Appaix F, Duteyrat JL, Henry M, Vollaire J, Ayad…

eLife 2025