Institut pour
l’Avancée des Biosciences

A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma.

Arnold CS, Alazzi AM, Shunmugam S, Janouškovec J, Berry L, Charital S, Gautier T, Duley…

Nature Communications 2025 Lipids are crucial for Apicomplexa survival in their human hosts. They can acquire lipids from the host cell and/or make its own in a relict non-photosynthetic and essential plastid, the apicoplast, which represents a plant-like Achilles’ Heel for the par

3-Benzylmenadiones and their Heteroaromatic Analogues Target the Apicoplast of Apicomplexa Parasites: Synthesis and Bioimaging Studies.

Dupouy B, Donzel M, Roignant M, Charital S, Keumoe R, Yamaryo-Botté Y, Feckler A, Bundschuh…

ACS Infectious Diseases 2025

A comprehensive study of the sperm head defects in MMAF condition and their impact on embryo development in mice

Jana Muroňová, Emeline Lambert, Chanyuth Thamwan, Zeina Wehbe, Magali Court, Geneviève Chevalier, Jessica Escoffier, Zine-Eddine…

Molecular Humain Reproduction 2025

A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions.

Bitew MA, Paredes-Santos TC, Maru P, Krishnamurthy S, Wang Y, Sangaré LO, Duley S, Yamaryo-Botté…

Nature Communications (accepted) 2025

A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei.

Zeeshan M, Blatov I, Yanase R, Ferguson DJP, Pashley SL, Chahine Z, Yamaryo-Botté Y, Mishra…

Elife 2025

A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma

Arnold CS et aL.

Nat Commun 2025 Toxoplasma gondii, an apicomplexan parasite and agent of the human disease toxoplasmosis, possesses a non-photosynthetic relic plastid, named the apicoplast. Thought to be evolved from a red algal plastid, the apicoplast houses major metabolic pathways, s

A recurrent loss-of-function variant in DRC1 causes non-syndromic severe asthenozoospermia with favorable intracytoplasmic sperm injection and pregnancy outcomes

Célia Tebbakh, Anne-Laure Barbotin, Guillaume Martinez, Angèle Boursier, Zeina Wehbe, Asma Hammouda, Nicolas Thierry-Mieg, Christophe…

Andrology 2025

Bipartite binding of the intrinsically disordered scaffold protein JIP1 to the kinase JNK1.

Orand, T., Delaforge, E., Lee, A., Kragelj, J., Davis, RJ., Palencia, A.*, Jensen, MR.*

Proceedings of the National Academy of Sciences of USA. 2025

Combined physical and biological contributions to radiotherapy enhancement by Lu-based nanoscintillators in pancreatic cancer models.

Stelse-Masson, S., Lytvynenko, X., Bedregal-Portugal, K., Aubrun, C., Lavaud, M., Kadri, M., Jacquet, T., Moriscot,…

Nanotheranostics 2025 Methods: In this paper, we study the ability of Lu 3 Al 5 O 12: Pr@ SiO 2, a lutetium-based nanoscintillator, to exert a radiation dose-enhancement effect in two human pancreatic cancer cell models, namely PANC-1 and MIA PaCa-2. Results: Lu 3 Al 5 O 12:

Deciphering the Contribution of Circular RNAs to Age-Related Decline in Sertoli Cell Survivor.

Manfrevola F, Mosca N, Mele VG, Chioccarelli T, Martinez G, Coutton C, Mattia M, Pezzullo…

Aging Cell 2025